The overall goal of these four interlocking and cooperative projects is to study the cellular and molecular basis of experimental and human autoimmune disease. Serologic, cellular, biochemical and molecular biology techniques will be used to analyze the genes and their products encoding the specificity of autoantibodies in patients with scleroderma and bowel diseases, class II antigens, as well as of critical molecules which play an important role in the cell cooperation such as the Fc receptor. Furthermore, cell cooperation between antigens presenting cells and major subpopulations of lymphocytes mediating either humoral or cellular autoimmune response will be studied by cellular, biochemical and molecular biology approaches. Each individual project has a major aim to provide important insights in the pathogenesis of autoimmune disease.
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| Perera, Lilani; Shao, Ling; Patel, Anjlee et al. (2007) Expression of nonclassical class I molecules by intestinal epithelial cells. Inflamm Bowel Dis 13:298-307 |
| Dotan, Iris; Allez, Matthieu; Nakazawa, Atsushi et al. (2007) Intestinal epithelial cells from inflammatory bowel disease patients preferentially stimulate CD4+ T cells to proliferate and secrete interferon-gamma. Am J Physiol Gastrointest Liver Physiol 292:G1630-40 |
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| Shao, Ling; Jacobs, Adam R; Johnson, Valrie V et al. (2005) Activation of CD8+ regulatory T cells by human placental trophoblasts. J Immunol 174:7539-47 |
| Brimnes, Jens; Allez, Matthieu; Dotan, Iris et al. (2005) Defects in CD8+ regulatory T cells in the lamina propria of patients with inflammatory bowel disease. J Immunol 174:5814-22 |
| Safadi, Rifaat; Alvarez, Carlos E; Ohta, Masayuki et al. (2005) Enhanced oral tolerance in transgenic mice with hepatocyte secretion of IL-10. J Immunol 175:3577-83 |
| Kraus, Thomas A; Brimnes, Jens; Muong, Christine et al. (2005) Induction of mucosal tolerance in Peyer's patch-deficient, ligated small bowel loops. J Clin Invest 115:2234-43 |
| Ando, Takao; Davies, Terry F (2005) Monoclonal antibodies to the thyrotropin receptor. Clin Dev Immunol 12:137-43 |
| Ando, Takao; Latif, Rauf; Daniel, Samira et al. (2004) Dissecting linear and conformational epitopes on the native thyrotropin receptor. Endocrinology 145:5185-93 |
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