Abstract

The animal facility core supports a special barrier type animal facility for breeding of unique strains of mice and for maintenance of mice in a specific pathogen free environment. This core will be utilized by all participants in the Program Project. Infectious agents, found in well maintained conventional mouse colony, are known to affect immune function in an uncontrolled fashion. """"""""Clean"""""""" mice are absolutely essential for the studies of the Program Project.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
2P01AI029531-08
Application #
6234970
Study Section
Project Start
1997-09-01
Project End
1998-08-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
8
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Chicago
Department
Type
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Gajewski, T F; Fallarino, F; Fields, P E et al. (2001) Absence of CTLA-4 lowers the activation threshold of primed CD8+ TCR-transgenic T cells: lack of correlation with Src homology domain 2-containing protein tyrosine phosphatase. J Immunol 166:3900-7
Szot, G L; Zhou, P; Rulifson, I et al. (2001) Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient mice. Am J Transplant 1:38-46
Alegre, M; Fallarino, F; Zhou, P et al. (2001) Transplantation and the CD28/CTLA4/B7 pathway. Transplant Proc 33:209-11
Zhou, P; Szot, G L; Guo, Z et al. (2000) Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance. J Immunol 165:5580-7
Kulkarni, S; Holman, P O; Kopelan, A et al. (2000) Programmed cell death signaling via cell-surface expression of a single-chain antibody transgene. Transplantation 69:1209-17
Rezai, K A; Semnani, R T; Farrokh-Siar, L et al. (1999) Human fetal retinal pigment epithelial cells induce apoptosis in allogenic T-cells in a Fas ligand and PGE2 independent pathway. Curr Eye Res 18:430-9
van Seventer, G A; Semnani, R T; Palmer, E M et al. (1998) Integrins and T helper cell activation. Transplant Proc 30:4270-4
Smith, J A; Tang, Q; Bluestone, J A (1998) Partial TCR signals delivered by FcR-nonbinding anti-CD3 monoclonal antibodies differentially regulate individual Th subsets. J Immunol 160:4841-9
Fields, P E; Finch, R J; Gray, G S et al. (1998) B7.1 is a quantitatively stronger costimulus than B7.2 in the activation of naive CD8+ TCR-transgenic T cells. J Immunol 161:5268-75
Madrenas, J; Chau, L A; Smith, J et al. (1997) The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands. J Exp Med 185:219-29

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