Abstract

The core will provide support for administrative and technical personnel who are vital to the success of the three components of AADRC. In addition, it will provide funds to maintain the FACSCalibur, a piece of equipment that is that are vital to AADRC investigators. The Principal Investigator will ensure that the AADRC functions in a cohesive integrated fashion. He will interact with the research grant administrators at the NIH, Children s Hospital and Harvard School of Public Health to administer the grant. The technical part of the core will serve the FACS analysis needs of the projects and will breed maintain the transgenic mice shared between projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
2P01AI031541-09
Application #
6212512
Study Section
Special Emphasis Panel (ZAI1-PTM-I (M1))
Project Start
1991-09-30
Project End
2003-08-31
Budget Start
Budget End
Support Year
9
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Burton, Oliver T; Stranks, Amanda J; Tamayo, Jaciel M et al. (2017) A humanized mouse model of anaphylactic peanut allergy. J Allergy Clin Immunol 139:314-322.e9
Boboila, Cristian; Oksenych, Valentyn; Gostissa, Monica et al. (2012) Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1). Proc Natl Acad Sci U S A 109:2473-8
Ozcan, Esra; Rauter, Ingrid; Garibyan, Lilit et al. (2011) Toll-like receptor 9, transmembrane activator and calcium-modulating cyclophilin ligand interactor, and CD40 synergize in causing B-cell activation. J Allergy Clin Immunol 128:601-9.e1-4
Fried, Ari J; Rauter, Ingrid; Dillon, Stacey R et al. (2011) Functional analysis of transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) mutations associated with common variable immunodeficiency. J Allergy Clin Immunol 128:226-228.e1
Greenblatt, Matthew B; Aliprantis, Antonios; Hu, Bella et al. (2010) Calcineurin regulates innate antifungal immunity in neutrophils. J Exp Med 207:923-31
Boboila, Cristian; Yan, Catherine; Wesemann, Duane R et al. (2010) Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. J Exp Med 207:417-27
Lee, John J; Jabara, Haifa H; Garibyan, Lilit et al. (2010) The C104R mutant impairs the function of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) through haploinsufficiency. J Allergy Clin Immunol 126:1234-41.e2
Zhang, Tingting; Franklin, Andrew; Boboila, Cristian et al. (2010) Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions. Proc Natl Acad Sci U S A 107:3040-5
Boboila, Cristian; Jankovic, Mila; Yan, Catherine T et al. (2010) Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proc Natl Acad Sci U S A 107:3034-9
Ozcan, Esra; Garibyan, Lilit; Lee, John Jhe-Yun et al. (2009) Transmembrane activator, calcium modulator, and cyclophilin ligand interactor drives plasma cell differentiation in LPS-activated B cells. J Allergy Clin Immunol 123:1277-86.e5

Showing the most recent 10 out of 23 publications