Abstract

The Clinical core will provide patient materials and epidemiologic information to each of the sub-projects as needed to complete their interactions. The core patient group will consist of women identified as recent contacts to men with chlamydial or gonococcal infection. Most (but not all) of the women will be infected. The study design ensures that most of the women have had only a single contact (to maintain the link in transmission) and, based on preliminary evidence, most will be infected.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI033087-02
Application #
3769688
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Muhlecker, W; Gulati, S; McQuillen, D P et al. (1999) An essential saccharide binding domain for the mAb 2C7 established for Neisseria gonorrhoeae LOS by ES-MS and MSn. Glycobiology 9:157-71
McQuillen, D P; Gulati, S; Ram, S et al. (1999) Complement processing and immunoglobulin binding to Neisseria gonorrhoeae determined in vitro simulates in vivo effects. J Infect Dis 179:124-35
Qureshi, N; Kaltashov, I; Walker, K et al. (1997) Structure of the monophosphoryl lipid A moiety obtained from the lipopolysaccharide of Chlamydia trachomatis. J Biol Chem 272:10594-600
Lo, S K; Golenbock, D T; Sass, P M et al. (1997) Engagement of the Lewis X antigen (CD15) results in monocyte activation. Blood 89:307-14
Gulati, S; McQuillen, D P; Mandrell, R E et al. (1996) Immunogenicity of Neisseria gonorrhoeae lipooligosaccharide epitope 2C7, widely expressed in vivo with no immunochemical similarity to human glycosphingolipids. J Infect Dis 174:1223-37
Gulati, S; McQuillen, D P; Sharon, J et al. (1996) Experimental immunization with a monoclonal anti-idiotope antibody that mimics the Neisseria gonorrhoeae lipooligosaccharide epitope 2C7. J Infect Dis 174:1238-48
Ingalls, R R; Golenbock, D T (1995) CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide. J Exp Med 181:1473-9
Golenbock, D T; Bach, R R; Lichenstein, H et al. (1995) Soluble CD14 promotes LPS activation of CD14-deficient PNH monocytes and endothelial cells. J Lab Clin Med 125:662-71
Delude, R L; Savedra Jr, R; Zhao, H et al. (1995) CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition. Proc Natl Acad Sci U S A 92:9288-92
Ingalls, R R; Rice, P A; Qureshi, N et al. (1995) The inflammatory cytokine response to Chlamydia trachomatis infection is endotoxin mediated. Infect Immun 63:3125-30

Showing the most recent 10 out of 15 publications