The Animal Facility Core will meet the needs of the Program Project Grant members for creatingnew mouse strains and for established, shared strains. To improve efficiencies the Core will provide andmaintain genetically complex animals that are used by multiple projects, assist with backcrosses, and alsoassist with mice used in genetic mapping projects. There are four SPECIFIC AIMS for this Core.1. To breed and genetically characterize unique and non-routine mouse strains for use by all the programproject members. This service will ensure that animals are readily available for use in experiments for all ofthe PPG members.2. To assist program project members with routine backcrossing of newly obtained or derived strains to theappropriate genetic backgrounds for planned studies. Fixed genetic backgrounds will be essential for manyof the studies in the PPG.3. To provide breeding and collection services for genetic mapping projects that are being performed in twoof the projects in the PPG (projects 3 and 4). The Core will help with the maintenance and generation ofanimals in these crosses, as well as collection of DNA for genotyping.4. To ensure animals provided to program project members are healthy and maintained in a pathogen-freeenvironment for the proposed studies.The availability of the mouse Core will ensure that multiple investigators in the PPG will have sufficientanimals available for their studies in a timely and efficient manner.
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