Abstract

All four projects in the Program entail a heavy commitment to flow cytometric analysis and cell sorting. We will meet this need by increasing the capacity of the Yale Immunobiology FACS Facility. The only practicable and cost-effective way to do this is to employ a second research specialist, who will extend the working day of the cell sorter from 7.5 to 12 hours, and institute scheduled operation and preventive maintenance for the two analytical flow cytometers.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI036529-07
Application #
6340675
Study Section
Project Start
2000-09-01
Project End
2001-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
7
Fiscal Year
2000
Total Cost
$133,337
Indirect Cost

  Institution

Name
Yale University
Department
Type
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Doyle, Hester A; Mamula, Mark J (2012) Autoantigenesis: the evolution of protein modifications in autoimmune disease. Curr Opin Immunol 24:112-8
Kamanaka, Masahito; Huber, Samuel; Zenewicz, Lauren A et al. (2011) Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology. J Exp Med 208:1027-40
Choi, Je-Min; Shin, Jae-Hun; Sohn, Myung-Hyun et al. (2010) Cell-permeable Foxp3 protein alleviates autoimmune disease associated with inflammatory bowel disease and allergic airway inflammation. Proc Natl Acad Sci U S A 107:18575-80
Sweet, Rebecca A; Christensen, Sean R; Harris, Michelle L et al. (2010) A new site-directed transgenic rheumatoid factor mouse model demonstrates extrafollicular class switch and plasmablast formation. Autoimmunity 43:607-18
Sanjabi, Shomyseh; Zenewicz, Lauren A; Kamanaka, Masahito et al. (2009) Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity. Curr Opin Pharmacol 9:447-53
Herlands, Robin A; Christensen, Sean R; Sweet, Rebecca A et al. (2008) T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells. Immunity 29:249-60
Shlomchik, Mark J (2008) Sites and stages of autoreactive B cell activation and regulation. Immunity 28:18-28
Christensen, Sean R; Shlomchik, Mark J (2007) Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptors. Semin Immunol 19:11-23
Herlands, Robin A; William, Jacqueline; Hershberg, Uri et al. (2007) Anti-chromatin antibodies drive in vivo antigen-specific activation and somatic hypermutation of rheumatoid factor B cells at extrafollicular sites. Eur J Immunol 37:3339-51
Harvey, Bohdan P; Gee, Renelle J; Haberman, Ann M et al. (2007) Antigen presentation and transfer between B cells and macrophages. Eur J Immunol 37:1739-51

Showing the most recent 10 out of 79 publications