Project Start
1999-09-01
Project End
2001-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Havari, Evis; Lennon-Dumenil, Ana Maria; Klein, Ludger et al. (2004) Expression of the B7.1 costimulatory molecule on pancreatic beta cells abrogates the requirement for CD4 T cells in the development of type 1 diabetes. J Immunol 173:787-96
Taylor, Jacqueline A; Havari, Evis; McInerney, Marcia F et al. (2004) A spontaneous model for autoimmune myocarditis using the human MHC molecule HLA-DQ8. J Immunol 172:2651-8
Lee, K H; Wucherpfennig, K W; Wiley, D C (2001) Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes. Nat Immunol 2:501-7
Wucherpfennig, K W (2001) Insights into autoimmunity gained from structural analysis of MHC-peptide complexes. Curr Opin Immunol 13:650-6
Yu, B; Gauthier, L; Hausmann, D H et al. (2000) Binding of conserved islet peptides by human and murine MHC class II molecules associated with susceptibility to type I diabetes. Eur J Immunol 30:2497-506
Hausmann, D H; Yu, B; Hausmann, S et al. (1999) pH-dependent peptide binding properties of the type I diabetes-associated I-Ag7 molecule: rapid release of CLIP at an endosomal pH. J Exp Med 189:1723-34
Ding, Y H; Baker, B M; Garboczi, D N et al. (1999) Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical. Immunity 11:45-56
Baker, B M; Ding, Y H; Garboczi, D N et al. (1999) Structural, biochemical, and biophysical studies of HLA-A2/altered peptide ligands binding to viral-peptide-specific human T-cell receptors. Cold Spring Harb Symp Quant Biol 64:235-41
Smith, K J; Pyrdol, J; Gauthier, L et al. (1998) Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein. J Exp Med 188:1511-20