Abstract

The mouse core is devoted to production of non-commercially available murine lines and maintenance of all mice used in conjunction with this program project. This includes all purchased animals, mice bred specifically for use in this program, and all maintenance of all experimental animals. The operation of such a core is justified by the significant overlap among investigators in the transgenic lines used in each project and by the fact that many experiments will be performed as collaborative efforts. It is anticipated that there will be equal use of the animal core by each investigator.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
1P01AI039664-03
Application #
6268240
Study Section
Project Start
1998-06-01
Project End
1999-05-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Camacho, S A; Heath, W R; Carbone, F R et al. (2001) A key role for ICAM-1 in generating effector cells mediating inflammatory responses. Nat Immunol 2:523-9
Ragazzo, J L; Ozaki, M E; Karlsson, L et al. (2001) Costimulation via lymphocyte function-associated antigen 1 in the absence of CD28 ligation promotes anergy of naive CD4+ T cells. Proc Natl Acad Sci U S A 98:241-6
Ozaki, M E; Webb, S R (2000) Controlling mature CD4+ T cell responses. Immunol Res 21:345-55
Nugent, C T; Morgan, D J; Biggs, J A et al. (2000) Characterization of CD8+ T lymphocytes that persist after peripheral tolerance to a self antigen expressed in the pancreas. J Immunol 164:191-200
Gallichan, W S; Balasa, B; Davies, J D et al. (1999) Pancreatic IL-4 expression results in islet-reactive Th2 cells that inhibit diabetogenic lymphocytes in the nonobese diabetic mouse. J Immunol 163:1696-703
Kreuwel, H T; Morgan, D J; Krahl, T et al. (1999) Comparing the relative role of perforin/granzyme versus Fas/Fas ligand cytotoxic pathways in CD8+ T cell-mediated insulin-dependent diabetes mellitus. J Immunol 163:4335-41
Morgan, D J; Kreuwel, H T; Sherman, L A (1999) Antigen concentration and precursor frequency determine the rate of CD8+ T cell tolerance to peripherally expressed antigens. J Immunol 163:723-7
Morgan, D J; Kurts, C; Kreuwel, H T et al. (1999) Ontogeny of T cell tolerance to peripherally expressed antigens. Proc Natl Acad Sci U S A 96:3854-8
Ozaki, M E; Coren, B A; Huynh, T N et al. (1999) CD4+ T cell responses to CD40-deficient APCs: defects in proliferation and negative selection apply only with B cells as APCs. J Immunol 163:5250-6
Gallichan, W S; Kafri, T; Krahl, T et al. (1998) Lentivirus-mediated transduction of islet grafts with interleukin 4 results in sustained gene expression and protection from insulitis. Hum Gene Ther 9:2717-26

Showing the most recent 10 out of 11 publications