The mouse core will be responsible for breeding and providing all mice needed by the Projects within theProgram project. The anticipated usage of this core by these three Projects will be: Project 1 (40%), Project2 (30%), Project 3 (30%). This mouse core will be a component of the Wakeland mouse colony (WMC),which is an SPF colony containing >1500 cages (~5000 daily census). This core has two specific aims. Thefirst specific aim will be to maintain all of the various mouse strains required by PPG investigators and toproduce and provide mice for use in all experiments. This will require the maintenance of more than 40unique strains of mice. The core will be responsible for maintaining breeding records, validating thegenotypes of all the B6-congenic strains, and producing experimental cohorts of mice as needed forexperiments by personnel in Projects 1, 2, and 3. The second specific aim will be to produce and genotypethe new strains that will be produced by all of the projects. This will include breeding all transgene founderstrains and introgressing the selected transgene founders onto specific genotypes. The core is alsoresponsible for breeding and shipping mice to other investigators in the biomedical research communityrequesting access to the mice in our collection.
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