Abstract

Intradermal gene vaccination of rodents with naked plasmid DNA (pDNA) has been previously shown to deviate an ongoing Th2 mediated IgE response to a predominately Th1 response. In order to test further refined vaccination strategies and elucidate the cellular mechanisms involved in t his phenomenon individual investigators have proposed extensive rodent studies. Therefore an Animal Core will be established to 1) breed and provide sufficient number of mice from strains that are not commmerically available to individual investigators, 2) routinely provide technical assistance to the investigators with ear punching, bleeding and injecting mice, and 3) provide service to scientific investigators by assisting with animal care, drug administratioin and special procedures.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI040682-03
Application #
6201356
Study Section
Project Start
1999-09-01
Project End
2000-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Lee, Jongdae; Abe, Kazumichi; Katakura, Kyoko et al. (2009) The protective effects of type-1 interferon in models of intestinal inflammation. Adv Exp Med Biol 633:1-6
Hayashi, Tomoko; Cottam, Howard B; Chan, Michael et al. (2008) Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7. Am J Physiol Regul Integr Comp Physiol 295:R123-32
Wu, Christina C N; Sabet, Mojgan; Hayashi, Tomoko et al. (2008) In vivo efficacy of a phosphodiester TLR-9 aptamer and its beneficial effect in a pulmonary anthrax infection model. Cell Immunol 251:78-85
Lee, Jongdae; Gonzales-Navajas, Jose M; Raz, Eyal (2008) The ""polarizing-tolerizing"" mechanism of intestinal epithelium: its relevance to colonic homeostasis. Semin Immunopathol 30:3-9
Lane, Nancy E; Nevitt, Michael C; Lui, Li-Yung et al. (2007) Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women. Arthritis Rheum 56:3319-25
Batzer, Glenda; Lam, Diane P; Paulus, Petra et al. (2007) Using house dust extracts to understand the immunostimulatory activities of living environments. Immunobiology 212:491-8
Hayashi, Tomoko; Mo, Ji-Hun; Gong, Xing et al. (2007) 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis. Proc Natl Acad Sci U S A 104:18619-24
Abe, Kazumichi; Nguyen, Kim Phung; Fine, Sean D et al. (2007) Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells. Proc Natl Acad Sci U S A 104:17022-7
Raz, Eyal (2007) Organ-specific regulation of innate immunity. Nat Immunol 8:3-4
Wu, Christina C N; Hayashi, Tomoko; Takabayashi, Kenji et al. (2007) Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand. Proc Natl Acad Sci U S A 104:3990-5

Showing the most recent 10 out of 88 publications