Abstract

We have proposed ,an Administrative Core to centralize certain functions of the Program Project, includinggrant management, travel, communications, and;,publications. Although these functions could be carried outseparately within the projects^ having a central Administrative Core streamlines much of.the process,reduces duplication of effort, and leaves the individual program leaders free to pursue science, allowing theAdministrative Coordinator to manage these other aspects of the grant. Since the Program Project involvesinvestigators at 3 institutions and 2 cities, it is particularly important to. have a central 'clearinghouse' tocoordinate scientific and administrative matters. .

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI041521-12
Application #
7694143
Study Section
Special Emphasis Panel (ZAI1-PA-I (M2))
Project Start
2008-07-01
Project End
2012-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
12
Fiscal Year
2008
Total Cost
$87,043
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Fan, Martin Y; Low, Jun Siong; Tanimine, Naoki et al. (2018) Differential Roles of IL-2 Signaling in Developing versus Mature Tregs. Cell Rep 25:1204-1213.e4
Priyadharshini, Bhavana; Loschi, Michael; Newton, Ryan H et al. (2018) Cutting Edge: TGF-? and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets. J Immunol 201:2215-2219
Kean, Leslie S; Turka, Laurence A; Blazar, Bruce R (2017) Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy. Immunol Rev 276:192-212
Alessandrini, Alessandro; Turka, Laurence A (2017) FOXP3-Positive Regulatory T Cells and Kidney Allograft Tolerance. Am J Kidney Dis 69:667-674
Carlson, Alicia L; Fujisaki, Joji; Wu, Juwell et al. (2013) Tracking single cells in live animals using a photoconvertible near-infrared cell membrane label. PLoS One 8:e69257
Zhao, X; Boenisch, O; Yeung, M et al. (2012) Critical role of proinflammatory cytokine IL-6 in allograft rejection and tolerance. Am J Transplant 12:90-101
Koulmanda, Maria; Bhasin, Manoj; Awdeh, Zuheir et al. (2012) The role of TNF-? in mice with type 1- and 2- diabetes. PLoS One 7:e33254
Harris, John E; Harris, Tajie H; Weninger, Wolfgang et al. (2012) A mouse model of vitiligo with focused epidermal depigmentation requires IFN-ýý for autoreactive CD8ýýý T-cell accumulation in the skin. J Invest Dermatol 132:1869-76
Lieberman, Scott M; Kim, Jiyeon S; Corbo-Rodgers, Evann et al. (2012) Site-specific accumulation of recently activated CD4+ Foxp3+ regulatory T cells following adoptive transfer. Eur J Immunol 42:1429-35
Ueno, Takuya; Yeung, Melissa Y; McGrath, Martina et al. (2012) Intact B7-H3 signaling promotes allograft prolongation through preferential suppression of Th1 effector responses. Eur J Immunol 42:2343-53

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