Abstract

The Medical Mycology Core will be an integral part of all four projects and represents an important resource for fungal identifications, procurement and storage of strains, large-scale genetic crosses and in vitro susceptibility. This Core will provide all molecular typing methods for strain identification including karyotypes and PCR fingerprinting. The Core will perform the data collection, quality control issues, and handling of animal experiments. The core will also collate and cord all mutants and strains.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI044975-02
Application #
6299765
Study Section
Project Start
2000-03-01
Project End
2001-02-28
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
2
Fiscal Year
2000
Total Cost
$151,494
Indirect Cost

  Institution

Name
Duke University
Department
Type
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Chen, Jianghan; Varma, Ashok; Diaz, Mara R et al. (2008) Cryptococcus neoformans strains and infection in apparently immunocompetent patients, China. Emerg Infect Dis 14:755-62
Litvintseva, Anastasia P; Lin, Xiaorong; Templeton, Irka et al. (2007) Many globally isolated AD hybrid strains of Cryptococcus neoformans originated in Africa. PLoS Pathog 3:e114
Litvintseva, Anastasia P; Thakur, Rameshwari; Vilgalys, Rytas et al. (2006) Multilocus sequence typing reveals three genetic subpopulations of Cryptococcus neoformans var. grubii (serotype A), including a unique population in Botswana. Genetics 172:2223-38
Kingsbury, Joanne M; Goldstein, Alan L; McCusker, John H (2006) Role of nitrogen and carbon transport, regulation, and metabolism genes for Saccharomyces cerevisiae survival in vivo. Eukaryot Cell 5:816-24
Xue, Chaoyang; Bahn, Yong-Sun; Cox, Gary M et al. (2006) G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans. Mol Biol Cell 17:667-79
Bahn, Yong-Sun; Kojima, Kaihei; Cox, Gary M et al. (2005) Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans. Mol Biol Cell 16:2285-300
Fan, Weihua; Kraus, Peter R; Boily, Marie-Josee et al. (2005) Cryptococcus neoformans gene expression during murine macrophage infection. Eukaryot Cell 4:1420-33
Blankenship, Jill R; Heitman, Joseph (2005) Calcineurin is required for Candida albicans to survive calcium stress in serum. Infect Immun 73:5767-74
Hull, Christina M; Boily, Marie-Josee; Heitman, Joseph (2005) Sex-specific homeodomain proteins Sxi1alpha and Sxi2a coordinately regulate sexual development in Cryptococcus neoformans. Eukaryot Cell 4:526-35
Litvintseva, Anastasia P; Kestenbaum, Lori; Vilgalys, Rytas et al. (2005) Comparative analysis of environmental and clinical populations of Cryptococcus neoformans. J Clin Microbiol 43:556-64

Showing the most recent 10 out of 85 publications