The cell envelope of M. tuberculosis is the focus, and, specifically, in the case of Project 1, fatty acid and mycolic acid anabolism and transfer and the exploitation of promising SB lead compounds, and, in the case of Project 2, inhibition of mycolic acid synthesis and deposition. Project 3 addresses the virgin area of isoprenoid biosynthesis, especially its unique bacterial/mycobacterial features in light of the action of azole compounds and other known antagonists of isoprenoid biosynthesis. Project 4 sharply focuses, for purposes of drug discovery, on the magnum opus of past NCDDG-01 support, i.e., the full elucidation of the biosynthesis of the cell wall arabinogalactan-linker unit, with its array of unique Rhap, Galf and Araf synthetic enzymes and corresponding glycosyltransferases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI046393-02
Application #
6171085
Study Section
Special Emphasis Panel (ZAI1-VSG-A (S2))
Program Officer
Laughon, Barbara E
Project Start
1999-09-30
Project End
2003-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
2
Fiscal Year
2000
Total Cost
$701,902
Indirect Cost
Name
Colorado State University-Fort Collins
Department
Microbiology/Immun/Virology
Type
Schools of Veterinary Medicine
DUNS #
112617480
City
Fort Collins
State
CO
Country
United States
Zip Code
80523
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Schaeffer, M L Merrill L; Carson, J D Jeffrey D; Kallender, Howard et al. (2004) Development of a scintillation proximity assay for the Mycobacterium tuberculosis KasA and KasB enzymes involved in mycolic acid biosynthesis. Tuberculosis (Edinb) 84:353-60
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