Abstract

The major objective of the Statistical Core is to collect, analyze and integrate the data from all three of the projects in our program. This core will include consultation for the design of HPV vaccine studies and sampling size of the proposed immunological assays. The significant function of this Statistical Core is that through a centralized collection, analysis and integrated interpretation of the data generated from each of the three projects with patients' clinical information, it will be possible to identify the most relevant immunological parameters that significantly correlate with clinical, virologic and pathologic outcomes. Furthermore, centralization of all the immunological data from each project and compilation of patients' clinical information by this Core will substantially reduce the overall cost and manpower needs.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI048203-03
Application #
6606024
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2002-07-01
Project End
2003-06-30
Budget Start
Budget End
Support Year
3
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Yang, Rongcun; Wheeler, Cosette M; Chen, Xiaojiang et al. (2005) Papillomavirus capsid mutation to escape dendritic cell-dependent innate immunity in cervical cancer. J Virol 79:6741-50
Yang, Rongcun; Murillo, Francisco Martinez; Delannoy, Michael J et al. (2005) B lymphocyte activation by human papillomavirus-like particles directly induces Ig class switch recombination via TLR4-MyD88. J Immunol 174:7912-9
Pinto, Ligia A; Castle, Philip E; Roden, Richard B et al. (2005) HPV-16 L1 VLP vaccine elicits a broad-spectrum of cytokine responses in whole blood. Vaccine 23:3555-64
Kim, Tae Woo; Lee, Jin Hyup; Hung, Chien-Fu et al. (2004) Generation and characterization of DNA vaccines targeting the nucleocapsid protein of severe acute respiratory syndrome coronavirus. J Virol 78:4638-45
Yang, Rongcun; Murillo, Francisco Martinez; Lin, Ken-Yu et al. (2004) Human papillomavirus type-16 virus-like particles activate complementary defense responses in key dendritic cell subpopulations. J Immunol 173:2624-31
Yang, Rongcun; Murillo, Francisco Martinez; Cui, Hengmi et al. (2004) Papillomavirus-like particles stimulate murine bone marrow-derived dendritic cells to produce alpha interferon and Th1 immune responses via MyD88. J Virol 78:11152-60
Peng, Shiwen; Ji, Hongxiu; Trimble, Cornelia et al. (2004) Development of a DNA vaccine targeting human papillomavirus type 16 oncoprotein E6. J Virol 78:8468-76
Cheng, W F; Hung, C F; Lin, K Y et al. (2003) CD8+ T cells, NK cells and IFN-gamma are important for control of tumor with downregulated MHC class I expression by DNA vaccination. Gene Ther 10:1311-20
Yang, Rongcun; Yutzy 4th, William H; Viscidi, Raphael P et al. (2003) Interaction of L2 with beta-actin directs intracellular transport of papillomavirus and infection. J Biol Chem 278:12546-53
Roden, R B; Day, P M; Bronzo, B K et al. (2001) Positively charged termini of the L2 minor capsid protein are necessary for papillomavirus infection. J Virol 75:10493-7