The Administrative Core will be responsible for providing scientific administration and coordination, fiscal oversight and administrative support for this Program Project Grant, to enable this PPG to continue to be a highly interactive and integrated program. The Administrative Core will coordinate PPG scientific group meetings among investigators at Harvard Medical School, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Massachusetts General Hospital, Emory University and the University of Minnesota using video conferencing and telephone conference calls. The Administrative Core will provide effective communication services to enable PPG investigators to share data, plan experiments, and enhance their collaborations. In addition, the Administrative Core will arrange an annual PPG meeting for investigators in Boston. Administratively, this Core will coordinate annual progress reports and renewal of sub-contract agreements, and will liaise between the grants offices of the various institutions and the Harvard Medical School Sponsored Programs Administration office. Dr. Arlene Sharpe, as Program Project Principal investigator and her institution Harvard Medical School, will be responsible for this application and for the collaborative research activities described. Dr. Arlene Sharpe will direct this Core with the support of her administrative assistant Sarah Hillman and grants administrator Sandra Hatten. Core A has the following Specific Aims.
Aim 1 : To provide administrate support for the PPG by facilitating optimal interactions among all participants in the PPG;coordinating the three PPG projects with the two scientific cores;maintaining fair, effective communication and cooperation among program investigators; Managing program activities and contractual agreements;Overseeing allocation of funds;and providing a measure of oversight for PPG through the Scientific Advisory Board, and Aim 2: To maintain a web-based secure portal for data sharing to facilitate sharing of data in real time, planning of future experiments and collaboration.
| Wu, Chuan; Chen, Zuojia; Xiao, Sheng et al. (2018) SGK1 Governs the Reciprocal Development of Th17 and Regulatory T Cells. Cell Rep 22:653-665 |
| Juchem, Kathryn W; Sacirbegovic, Faruk; Zhang, Cuiling et al. (2018) PD-L1 Prevents the Development of Autoimmune Heart Disease in Graft-versus-Host Disease. J Immunol 200:834-846 |
| Priyadharshini, Bhavana; Loschi, Michael; Newton, Ryan H et al. (2018) Cutting Edge: TGF-? and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets. J Immunol 201:2215-2219 |
| Porichis, Filippos; Hart, Meghan G; Massa, Alexandra et al. (2018) Immune Checkpoint Blockade Restores HIV-Specific CD4 T Cell Help for NK Cells. J Immunol 201:971-981 |
| LaFleur, Martin W; Muroyama, Yuki; Drake, Charles G et al. (2018) Inhibitors of the PD-1 Pathway in Tumor Therapy. J Immunol 200:375-383 |
| Chaudhri, Apoorvi; Xiao, Yanping; Klee, Alyssa N et al. (2018) PD-L1 Binds to B7-1 Only In Cis on the Same Cell Surface. Cancer Immunol Res 6:921-929 |
| Ahn, Eunseon; Araki, Koichi; Hashimoto, Masao et al. (2018) Role of PD-1 during effector CD8 T cell differentiation. Proc Natl Acad Sci U S A 115:4749-4754 |
| Wu, Yongxia; Schutt, Steven; Paz, Katelyn et al. (2018) MicroRNA-17-92 is required for T-cell and B-cell pathogenicity in chronic graft-versus-host disease in mice. Blood 131:1974-1986 |
| Gartlan, Kate H; Bommiasamy, Hemamalini; Paz, Katelyn et al. (2018) A critical role for donor-derived IL-22 in cutaneous chronic GVHD. Am J Transplant 18:810-820 |
| Hippen, Keli L; Loschi, Michael; Nicholls, Jemma et al. (2018) Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease. Front Immunol 9:57 |
Showing the most recent 10 out of 332 publications
