Our goal here is to understand how several candidate viral infections enhance autoimmune disease in multiple sclerosis (EAE) and diabetes disease models (von Herrath and Fujinami). The novel aspects addressed by this PPG are: 1. The hypothesis that viral infections will be able to provide a 'fertile field' for autoaggressive lymphocytes or enhance already pre-existing but sub-clinical autoimmune processes. 2. The detailed mechanistic analysis involving mimicry as well as bystander activation, in particular the understanding of the basic mechanistic aspects of virally triggered presentation of autoantigens and activation of autoaggressive lymphocytes from the APC/immuno-proteasome side (Whitton). The emerging findings will be useful in pursuing the link between viruses and autoimmunity in humans in a more directional/mechanistic way.
| Schneider, Darius A; von Herrath, Matthias G (2013) Viruses and Type 1 diabetes: a dynamic labile equilibrium. Diabetes Manag (Lond) 3:217-223 |
| Van Belle, Tom L; Nierkens, Stefan; Arens, Ramon et al. (2012) Interleukin-21 receptor-mediated signals control autoreactive T cell infiltration in pancreatic islets. Immunity 36:1060-72 |
| Libbey, Jane E; Tsunoda, Ikuo; Fujinami, Robert S (2012) Possible role of interleukin-17 in a prime/challenge model of multiple sclerosis. J Neurovirol 18:471-8 |
| Boettler, Tobias; Cunha-Neto, Edecio; Kalil, Jorge et al. (2012) Can an immune-regulatory vaccine prevent HIV infection? Expert Rev Anti Infect Ther 10:299-305 |
| Filippi, Christophe M; Ehrhardt, Katrin; Estes, Elizabeth A et al. (2011) TLR2 signaling improves immunoregulation to prevent type 1 diabetes. Eur J Immunol 41:1399-409 |
| Libbey, Jane E; Fujinami, Robert S (2011) Experimental autoimmune encephalomyelitis as a testing paradigm for adjuvants and vaccines. Vaccine 29:3356-62 |
| Fousteri, Georgia; Dave, Amy; Morin, Bret et al. (2011) Nasal cardiac myosin peptide treatment and OX40 blockade protect mice from acute and chronic virally-induced myocarditis. J Autoimmun 36:210-20 |
| van Belle, Tom L; Coppieters, Ken T; von Herrath, Matthias G (2011) Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiol Rev 91:79-118 |
| Bresson, Damien; Fousteri, Georgia; Manenkova, Yulia et al. (2011) Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment. J Autoimmun 37:342-51 |
| Van Belle, Tom L; Esplugues, Enric; Liao, Jeanette et al. (2011) Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model. J Immunol 187:2915-22 |
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