Abstract

This Tetramer Core will be used, based on expertise already established in our laboratory, initially to provide MHC class I tetramers (Db, Kb, Kd, Ld) for tracking of aggressive CD8 cells. In the longer run, MHC class II tetramers (established for I-Ab) will also be provided to all investigators of the Program Project Grant. This core will facilitate the production of large enough tetramer quantities for in-situ staining and produce tetramers that are continuously available (see comparison for staining with NIH core).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI058105-04
Application #
7446061
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
4
Fiscal Year
2007
Total Cost
$34,860
Indirect Cost

  Institution

Name
La Jolla Institute
Department
Type
DUNS #
603880287
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Schneider, Darius A; von Herrath, Matthias G (2013) Viruses and Type 1 diabetes: a dynamic labile equilibrium. Diabetes Manag (Lond) 3:217-223
Van Belle, Tom L; Nierkens, Stefan; Arens, Ramon et al. (2012) Interleukin-21 receptor-mediated signals control autoreactive T cell infiltration in pancreatic islets. Immunity 36:1060-72
Libbey, Jane E; Tsunoda, Ikuo; Fujinami, Robert S (2012) Possible role of interleukin-17 in a prime/challenge model of multiple sclerosis. J Neurovirol 18:471-8
Boettler, Tobias; Cunha-Neto, Edecio; Kalil, Jorge et al. (2012) Can an immune-regulatory vaccine prevent HIV infection? Expert Rev Anti Infect Ther 10:299-305
Filippi, Christophe M; Ehrhardt, Katrin; Estes, Elizabeth A et al. (2011) TLR2 signaling improves immunoregulation to prevent type 1 diabetes. Eur J Immunol 41:1399-409
Libbey, Jane E; Fujinami, Robert S (2011) Experimental autoimmune encephalomyelitis as a testing paradigm for adjuvants and vaccines. Vaccine 29:3356-62
Fousteri, Georgia; Dave, Amy; Morin, Bret et al. (2011) Nasal cardiac myosin peptide treatment and OX40 blockade protect mice from acute and chronic virally-induced myocarditis. J Autoimmun 36:210-20
van Belle, Tom L; Coppieters, Ken T; von Herrath, Matthias G (2011) Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiol Rev 91:79-118
Bresson, Damien; Fousteri, Georgia; Manenkova, Yulia et al. (2011) Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment. J Autoimmun 37:342-51
Van Belle, Tom L; Esplugues, Enric; Liao, Jeanette et al. (2011) Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model. J Immunol 187:2915-22

Showing the most recent 10 out of 27 publications