The extreme genetic diversity of HIV-1 isolates poses a major challenge for the development of an HIV vaccine. Recent studies in mice have suggested that using """"""""centralized"""""""" HIV-1 sequences in immunogens may be an effective strategy for minimizing the impact of this genetic diversity on the creation of effective vaccines. Simian immunodeficiency virus (SIV) and the simian human immunodeficiency virus (SHIV) infected rhesus monkeys provide a powerful model for evaluating potential HIV vaccine strategies. We will employ this animal model to explore the use of """"""""centralized"""""""" gene-based HIV-1 vaccine strategies for broadening the recognition specificity of vaccine-elicited immune responses. Specifically, we will use this model to explore the: 1. Selection of an optimal """"""""centralized"""""""" HIV-1 envelope immunogen. 2. Comparison of """"""""centralized"""""""" and contemporary HIV-1 gag-pol-nef immunogens. 3. Comparison of """"""""centralized"""""""" and multiclade HIV-1 immunogens 4. Assessment of recombinant MVA """"""""centralized"""""""" HIV-1 immunogens. 5. Evaluation of """"""""centralized"""""""" envelope subunit immunogens.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI061734-05
Application #
7756632
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2009-02-01
Project End
2010-01-31
Budget Start
2009-02-01
Budget End
2010-01-31
Support Year
5
Fiscal Year
2009
Total Cost
$373,357
Indirect Cost
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
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