Respiratory syncytial virus (RSV) causes a spectrum of disease in children ranging from upper respiratory infections to severe lower respiratory tract disease, such as bronchiolitis and pneumonia. Although the determinants of disease progression from the upper to the lower respiratory tract, severity of bronchiolitis, recurrences, and long-term morbidity, such as recurrent wheezing or asthma, are not fully understood, both host- and virus-specific factors appear to contribute to the pathogenesis and/or the outcome of this infection. The long-term goal of our P01 is to understand the role the mucosa plays in virus- and allergen-induced airway inflammation and remodeling. We will advance our aims and the field by providing new mechanisms by which innate viral and allergen stimuli produce epigenetic remodeling, oxidative injury and reprogramming of the innate mucosal interferon (IFN) response. The purpose of the Infant Bronchiolitis and Viral Core (IBVC) is to acquire high-quality, clinically annotated mucosal samples from a cohort of young children infected with respiratory syncytial virus (RSV), and to provide a centralized scientific resource that supports the need for optimized, homogeneous (highly reproducible) RSV preparations, immunoassay performance, and use of state-of-the art experimental mouse models of infection, which are required in research project (RP) RP1-RP3 of our P01. Efficient management and distribution of samples and data will ensure the success of the projects. Furthermore, the IBVC will provide services, technical and intellectual assistance to the P01 Center investigators in a functional, cost-efficient, and multi-user environment that will enhance the productivity of both individual and collaborative research programs. In addition to state-of-the-art equipment and methods, the key personnel of the IBVC provide scientific and technical expertise that greatly benefits the Center investigators in terms of experimental design, execution and interpretation, as well as, by providing a focus for collaborative interactions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
2P01AI062885-11
Application #
9573992
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2018-07-20
Budget End
2019-06-30
Support Year
11
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Texas Med Br Galveston
Department
Type
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555
Tian, Bing; Liu, Zhiqing; Yang, Jun et al. (2018) Selective Antagonists of the Bronchiolar Epithelial NF-?B-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation. Cell Rep 23:1138-1151
Ba, Xueqing; Boldogh, Istvan (2018) 8-Oxoguanine DNA glycosylase 1: Beyond repair of the oxidatively modified base lesions. Redox Biol 14:669-678
Visnes, Torkild; Cázares-Körner, Armando; Hao, Wenjing et al. (2018) Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science 362:834-839
Ochoa, Lorenzo F; Kholodnykh, Alexander; Villarreal, Paula et al. (2018) Imaging of Murine Whole Lung Fibrosis by Large Scale 3D Microscopy aided by Tissue Optical Clearing. Sci Rep 8:13348
Liu, Zhiqing; Tian, Bing; Chen, Haiying et al. (2018) Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. Eur J Med Chem 151:450-461
Bao, Xiaoyong; Kolli, Deepthi; Esham, Dana et al. (2018) Human Metapneumovirus Small Hydrophobic Protein Inhibits Interferon Induction in Plasmacytoid Dendritic Cells. Viruses 10:
Chahar, Harendra Singh; Corsello, Tiziana; Kudlicki, Andrzej S et al. (2018) Respiratory Syncytial Virus Infection Changes Cargo Composition of Exosome Released from Airway Epithelial Cells. Sci Rep 8:387
Hosoki, Koa; Rajarathnam, Krishna; Sur, Sanjiv (2018) Attenuation of murine allergic airway inflammation with a CXCR1/CXCR2 chemokine receptor inhibitor. Clin Exp Allergy :
Tian, Bing; Widen, Steven G; Yang, Jun et al. (2018) The NF?B subunit RELA is a master transcriptional regulator of the committed epithelial-mesenchymal transition in airway epithelial cells. J Biol Chem 293:16528-16545
Graber, Ted G; Rawls, Brandy L; Tian, Bing et al. (2018) Repetitive TLR3 activation in the lung induces skeletal muscle adaptations and cachexia. Exp Gerontol 106:88-100

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