While highly active anti-retroviral therapy (HAART) can suppress HIV-1 replication, treatment currently doesnot eradicate infection or prevent a low level of continued replication. The major objective of this project isdirected to defining the anatomic and cellular compartments in which HIV-1 is produced and persists beforeand during HAART, and from which infection re-emerges on discontinuation of HAART.
The Specific Aim ofthe project is to identify, characterize and quantify cellular sources of virus production and persistence in gutassociatedlymphatic tissues (GALT) and peripheral lymphatic tissues (LTs), using state-of-the-art in situTechnologies of in situ hybridization, in situ PCR, immunohistochemistry and quantitative image analysis,with the long-term goal of capitalizing on the new insights into HIV-1 reservoirs generated by this analysis todesign even more effective treatments.
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