Abstract

The biostatistical core will support the efforts of all 4 projects through study design, statistical analysis and preparation of manuscripts. The core will be lead by Dr. Reilly, and he will be assisted by an research assistant with experience in Biostatistics. This core will perform power analysis and participate in protocol design to ensure that the data that is collected will allow evaluation of project hypotheses. In addition, this core will supervise data entry procedures and regularly communicate with project leaders regarding the accumulation of data to ensure the highest quality data. This core will be responsible for all data analysis and will participate in the drafting of manuscripts that involve statistical analysis of the data. The core leader, Dr. Reilly, has worked with several of the project leaders previously and has extensive experience with the spatial and longitudinal data that will be generated by these investigations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI074340-05
Application #
8379832
Study Section
Special Emphasis Panel (ZAI1-CCH-A)
Project Start
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2014-08-31
Support Year
5
Fiscal Year
2012
Total Cost
$123,318
Indirect Cost
$27,992

  Institution

Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Kityo, Cissy; Makamdop, Krystelle Nganou; Rothenberger, Meghan et al. (2018) Lymphoid tissue fibrosis is associated with impaired vaccine responses. J Clin Invest 128:2763-2773
Estes, Jacob D; Kityo, Cissy; Ssali, Francis et al. (2017) Defining total-body AIDS-virus burden with implications for curative strategies. Nat Med 23:1271-1276
Cory, Theodore J; He, Hui; Winchester, Lee C et al. (2016) Alterations in P-Glycoprotein Expression and Function Between Macrophage Subsets. Pharm Res 33:2713-21
Lorenzo-Redondo, Ramon; Fryer, Helen R; Bedford, Trevor et al. (2016) Persistent HIV-1 replication maintains the tissue reservoir during therapy. Nature 530:51-56
Winchester, Lee C; Podany, Anthony T; Baldwin, Joshua S et al. (2015) Determination of the rifamycin antibiotics rifabutin, rifampin, rifapentine and their major metabolites in human plasma via simultaneous extraction coupled with LC/MS/MS. J Pharm Biomed Anal 104:55-61
Sanchez, Joyce L; Hunt, Peter W; Reilly, Cavan S et al. (2015) Lymphoid fibrosis occurs in long-term nonprogressors and persists with antiretroviral therapy but may be reversible with curative interventions. J Infect Dis 211:1068-75
Cory, Theodore J; Winchester, Lee C; Robbins, Brian L et al. (2015) A rapid spin through oil results in higher cell-associated concentrations of antiretrovirals compared with conventional cell washing. Bioanalysis 7:1447-55
Mitchell, Caroline; Roemer, Emily; Nkwopara, Evangelyn et al. (2014) Correlation between plasma, intracellular, and cervical tissue levels of raltegravir at steady-state dosing in healthy women. Antimicrob Agents Chemother 58:3360-5
Fletcher, Courtney V; Staskus, Kathryn; Wietgrefe, Stephen W et al. (2014) Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues. Proc Natl Acad Sci U S A 111:2307-12
Misemer, Benjamin S; Skubitz, Amy P N; Carlos Manivel, J et al. (2014) Expression of FAP, ADAM12, WISP1, and SOX11 is heterogeneous in aggressive fibromatosis and spatially relates to the histologic features of tumor activity. Cancer Med 3:81-90

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