Abstract

The goals of the Genotyping Core are to promote and facilitate the research undertaken by the Program Investigators, as well as to enhance interdisciplinary research capabilities. The Genotyping Core will provide support in terms of equipment and expertise related to the very sophisficated technology needed for the success of the Projects, including all equipment and methods needed for single nucleofide polymorphism (SNP) genotyping and SNP arrays. The Genotyping Core will be an integral part of the research team in the development and execution of research studies;as well as providing ongoing analytical and procedural advice throughout the life of each individual Project.
The specific aims of the Genotyping Core include:
Specific Aim 1 : Facilitate MHC genotyping for Project 1 Specific Aim 2: Provide genotyping support and services to complete genome-wide association studies (GWAS) Specific Aim 3: Provide genotyping support and services to complete the proposed fine-mapping and replication studies.

Public Health Relevance

The studies proposed in this POI include 3 genome-wide association studies and follow-up fine-mapping and replication. The expertise provided by the Genotyping core in the technologies required for this work is highly relevant to the overall objectives of the Program.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
1P01AI083194-01
Application #
7774765
Study Section
Special Emphasis Panel (ZAI1-KS-I (M1))
Project Start
2009-08-15
Project End
2014-07-31
Budget Start
2009-08-15
Budget End
2010-07-31
Support Year
1
Fiscal Year
2009
Total Cost
$304,380
Indirect Cost

  Institution

Name
Oklahoma Medical Research Foundation
Department
Type
DUNS #
077333797
City
Oklahoma City
State
OK
Country
United States
Zip Code
73104

  Publications

Patel, Zubin; Lu, Xiaoming; Miller, Daniel et al. (2018) A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus. Hum Mol Genet :
Hanscombe, Ken B; Morris, David L; Noble, Janelle A et al. (2018) Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans. Hum Mol Genet 27:3813-3824
Sun, Celi; Molineros, Julio E; Looger, Loren L et al. (2016) High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry. Nat Genet 48:323-30
Deng, Yun; Zhao, Jian; Sakurai, Daisuke et al. (2016) Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production. Ann Rheum Dis 75:2007-2013
Alarcón-Riquelme, Marta E; Ziegler, Julie T; Molineros, Julio et al. (2016) Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture. Arthritis Rheumatol 68:932-43
Lessard, Christopher J; Sajuthi, Satria; Zhao, Jian et al. (2016) Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans. Arthritis Rheumatol 68:1197-1209
Lu, Rufei; Munroe, Melissa E; Guthridge, Joel M et al. (2016) Dysregulation of innate and adaptive serum mediators precedes systemic lupus erythematosus classification and improves prognostic accuracy of autoantibodies. J Autoimmun 74:182-193
Munroe, Melissa E; Lu, Rufei; Zhao, Yan D et al. (2016) Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification. Ann Rheum Dis 75:2014-2021
Zhao, Jian; Giles, Brendan M; Taylor, Rhonda L et al. (2016) Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA. Ann Rheum Dis 75:242-52
Liu, Ke; Kurien, Biji T; Zimmerman, Sarah L et al. (2016) X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome. Arthritis Rheumatol 68:1290-1300

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