Our goal is to develop a safe and optimally effective, mesenchymal stem cell (MSC) based, cotransplant protocol in two nonhuman primate (NHP) transplantation models that can ultimately be tested in the clinical setting to improve long-term islet and renal allograft survival and function. We will utilize cynomolgus monkey models of cellular (Project 1) and solid organ (Project 2) transplantation, in conjunction with genomics and proteomics analyses (Core B), phenotyping and functional assays (Projects 1 and 2), as well as sophisticated tools for data analysis (Core C) to undertake the proposed studies. The overall goal of the Administrative Core is to coordinate the activities of the Projects and Cores to ensure consistency and active communication, as well as rigorous analysis of the data. Dr. Kenyon will serve as contact PI and Program Director and will work with Ms. Laura Velez to achieve the Aims of Core A.
Aim 1. To manage the administrative requirements of the Projects and Cores, including budgets, NIH reporting, publication processing and organization/coordination of monthly teleconferences and annual meetings among the Pls.
Aim 2. To track shipping and receipt of samples from Projects 1 (Miami, FL) and 2 (Chicago, IL) to the Proteomics and Genomics Core (Core B, La Jolla, CA).
Aim 3. To ensure transfer of data in a timely manner to the Supercomputing and Multidimensional Data Analysis Core (Core C).
Aim 4. To ensure that data is discussed among the team as soon as results become available, in order to maximize outcomes by identifying any technical or other problems early on. As Program Director and PI of Core A, it will be Dr. Kenyon's responsibility to coordinate the overall program and ensure that excellent communication is maintained regarding shared methods for conduct of the experiments in Projects 1 and 2, real time discussion of experimental results, quality of samples received by Core B and frequent entry of data into the Core C website.
The findings from this study may provide for novel and superior methods to enhance the engraftment and long-term survival of solid organ and cellular allografts. Core A will oversee communication among the PIs, the NIH and the research community, in order to ensure high quality research that may ultimately benefit the public.
| Black, Edgar F; Marini, Luigi; Vaidya, Ashwini et al. (2014) Using Hidden Markov Models to Determine Changes in Subject Data over Time, Studying the Immunoregulatory effect of Mesenchymal Stem Cells. Proc IEEE Int Conf Escience 1:83-91 |
| Antony, Anuja K; Rodby, Katherine; Tobin, Matthew K et al. (2013) Composite tissue allotransplantation and dysregulation in tissue repair and regeneration: a role for mesenchymal stem cells. Front Immunol 4:188 |
| Auletta, Jeffery J; Deans, Robert J; Bartholomew, Amelia M (2012) Emerging roles for multipotent, bone marrow-derived stromal cells in host defense. Blood 119:1801-9 |
| Auletta, Jeffery J; Bartholomew, Amelia M; Maziarz, Richard T et al. (2012) The potential of mesenchymal stromal cells as a novel cellular therapy for multiple sclerosis. Immunotherapy 4:529-47 |
