Abstract

Core D will provide the informatics, computational biology, and statistical support for the analysis of antibody somatic genetics and the correlation of antibody genetics with affinity, neutralization capacity, and other correlates of protection. Core D personnel have developed state-of-the-art tools that permit such analyses to be conducted, and will apply these tools to the data generated by the investigators in the P01 research teams. Furthermore, Core D researchers will continue to develop methods as needed by the group as a whole.

Public Health Relevance

Affinity maturation is a key component of the immune response to vaccines. Antibodies become the first line of defense in post-vaccine exposure to the targeted pathogen through affinity maturation. Sophisticated mathematical analysis applied to technologically advanced data assays will enhance our understanding of this important process and greatly facilitate the design of greatly improved next-generation vaccines.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI089618-03
Application #
8717175
Study Section
Special Emphasis Panel (ZAI1-LR-I (M1))
Project Start
2013-08-01
Project End
2016-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
3
Fiscal Year
2013
Total Cost
$24,844
Indirect Cost
$3,221

  Institution

Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Finney, Joel; Yeh, Chen-Hao; Kelsoe, Garnett et al. (2018) Germinal center responses to complex antigens. Immunol Rev 284:42-50
McCarthy, Kevin R; Watanabe, Akiko; Kuraoka, Masayuki et al. (2018) Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires. Immunity 48:174-184.e9
Raymond, Donald D; Bajic, Goran; Ferdman, Jack et al. (2018) Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody. Proc Natl Acad Sci U S A 115:168-173
Ferdman, Jack; Palladino, Giuseppe; Liao, Hua-Xin et al. (2018) Intra-seasonal antibody repertoire analysis of a subject immunized with an MF59®-adjuvanted pandemic 2009 H1N1 vaccine. Vaccine 36:5325-5332
Finney, Joel; Kelsoe, Garnett (2018) Poly- and autoreactivity of HIV-1 bNAbs: implications for vaccine design. Retrovirology 15:53
Liu, Yuhang; Pan, Junhua; Jenni, Simon et al. (2017) CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface. J Mol Biol 429:1829-1839
Liu, Yuhang; Pan, Junhua; Cai, Yongfei et al. (2017) Conformational States of a Soluble, Uncleaved HIV-1 Envelope Trimer. J Virol 91:
Kuraoka, Masayuki; Schmidt, Aaron G; Nojima, Takuya et al. (2016) Complex Antigens Drive Permissive Clonal Selection in Germinal Centers. Immunity 44:542-552
Raymond, Donald D; Stewart, Shaun M; Lee, Jiwon et al. (2016) Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain. Nat Med 22:1465-1469
Lee, Jiwon; Boutz, Daniel R; Chromikova, Veronika et al. (2016) Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination. Nat Med 22:1456-1464

Showing the most recent 10 out of 18 publications