Abstract

The Administrative Core (Core C) will provide organizational and administrative support to facilitate communications, reporting, budget management, and other tasks that interface with the two projects and two scientific cores. The administrative core will include Dr. Pamela J. Bjorkman as Core Leader, her Administrative Assistant, a Research Scientist in her lab, the Lab Administrator in Dr. Michel Nussenzweig's lab, and the Administrative Assistant for Dr. Jost Vielmetter, the Core A and Core B Leader. The Administrative Core will 1) Organize and govern the HIVRAD project and 2) Coordinate the interactions within the HIVRAD project and with the broader scientific community. This includes arranging formal communications among investigators, preparing protocol submissions and annual renewals to the Institutional Review Boards, coordinating material transfer agreements, preparing reports and manuscripts, monitoring budgets, planning annual meetings and monthly conference calls, maintaining the HIVRAD website, and generally overseeing the scientific and administrative needs of the Program Project. In addition, the Administrative Core staff will assist in the effective sharing of data by maintaining shared cloud-based notebooks and databases.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI100148-08
Application #
10062801
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
8
Fiscal Year
2021
Total Cost
Indirect Cost

  Institution

Name
California Institute of Technology
Department
Type
DUNS #
009584210
City
Pasadena
State
CA
Country
United States
Zip Code
91125

  Publications

Wang, Haoqing; Barnes, Christopher O; Yang, Zhi et al. (2018) Partially Open HIV-1 Envelope Structures Exhibit Conformational Changes Relevant for Coreceptor Binding and Fusion. Cell Host Microbe 24:579-592.e4
Stadtmueller, Beth M; Bridges, Michael D; Dam, Kim-Marie et al. (2018) DEER Spectroscopy Measurements Reveal Multiple Conformations of HIV-1 SOSIP Envelopes that Show Similarities with Envelopes on Native Virions. Immunity 49:235-246.e4
Gautam, Rajeev; Nishimura, Yoshiaki; Gaughan, Natalie et al. (2018) A single injection of crystallizable fragment domain-modified antibodies elicits durable protection from SHIV infection. Nat Med 24:610-616
Cohn, Lillian B; da Silva, Israel T; Valieris, Renan et al. (2018) Clonal CD4+ T cells in the HIV-1 latent reservoir display a distinct gene profile upon reactivation. Nat Med 24:604-609
Bournazos, Stylianos; Ravetch, Jeffrey V (2017) Anti-retroviral antibody Fc?R-mediated effector functions. Immunol Rev 275:285-295
Gristick, Harry B; Wang, Haoqing; Bjorkman, Pamela J (2017) X-ray and EM structures of a natively glycosylated HIV-1 envelope trimer. Acta Crystallogr D Struct Biol 73:822-828
Bournazos, Stylianos; Wang, Taia T; Dahan, Rony et al. (2017) Signaling by Antibodies: Recent Progress. Annu Rev Immunol 35:285-311
Bournazos, Stylianos; Ravetch, Jeffrey V (2017) Fc? Receptor Function and the Design of Vaccination Strategies. Immunity 47:224-233
Freund, Natalia T; Wang, Haoqing; Scharf, Louise et al. (2017) Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller. Sci Transl Med 9:
Mayer, Christian T; Gazumyan, Anna; Kara, Ervin E et al. (2017) The microanatomic segregation of selection by apoptosis in the germinal center. Science 358:

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