Abstract

? Administrative Core The Administrative Core will serve as a resource to the entire Bridging Antibody Fc-mediated Antiviral Functions Across Humans and Non-human Primates PO1, providing overall management, coordination and supervision of the program. The P01 director, Georgia Tomaras will serve as the leader of the Administrative Core, and experienced staff will be responsible for managing and coordinating the entire range of the PO1 activities, monitoring progress and ensuring that the overall goals of the program are implemented effectively and efficiently.
Specific Aims will include the following.
AIM 1. Provide Scientific Oversight.
AIM 2. Facilitate Communication across the Program.
AIM 3. Ensure Regulatory Compliance AIM 4. Provide Financial Oversight Through central management of all scientific, regulatory and financial activities of the program, the Administrative Core directly interacts with each of the Projects and Cores. Similarly, each of the Projects and Cores provide direct input to the Administrative Core through the participation of the Project and Core Leads and key investigators as part of the Program?s Executive Committee. Collectively, the administrative group at the Duke Human Vaccine Institute has substantial expertise in the management of multi-institution grants and will ensure success in the management of the Bridging Antibody Fc-mediated Antiviral Functions Across Humans and Non-human Primates P01.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
1P01AI120756-01A1
Application #
9140248
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2016-05-01
Project End
2021-04-30
Budget Start
2016-04-01
Budget End
2017-03-31
Support Year
1
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
Duke University
Department
Surgery
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Shah, Spandan V; Manickam, Cordelia; Ram, Daniel R et al. (2018) CMV Primes Functional Alternative Signaling in Adaptive ?g NK Cells but Is Subverted by Lentivirus Infection in Rhesus Macaques. Cell Rep 25:2766-2774.e3
Boesch, Austin W; Kappel, James H; Mahan, Alison E et al. (2018) Enrichment of high affinity subclasses and glycoforms from serum-derived IgG using Fc?Rs as affinity ligands. Biotechnol Bioeng 115:1265-1278
Cheng, Hao D; Grimm, Sebastian K; Gilman, Morgan Sa et al. (2018) Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site. JCI Insight 3:
Brown, Eric P; Weiner, Joshua A; Lin, Shu et al. (2018) Optimization and qualification of an Fc Array assay for assessments of antibodies against HIV-1/SIV. J Immunol Methods 455:24-33
Manickam, Cordelia; Nwanze, Chiadika; Ram, Daniel R et al. (2018) Progressive lentivirus infection induces natural killer cell receptor-expressing B cells in the gastrointestinal tract. AIDS 32:1571-1578
Ram, Daniel R; Manickam, Cordelia; Hueber, Brady et al. (2018) Tracking KLRC2 (NKG2C)+ memory-like NK cells in SIV+ and rhCMV+ rhesus macaques. PLoS Pathog 14:e1007104
Alter, Galit; Dowell, Karen G; Brown, Eric P et al. (2018) High-resolution definition of humoral immune response correlates of effective immunity against HIV. Mol Syst Biol 14:e7881
Wills, Saintedym; Hwang, Kwan-Ki; Liu, Pinghuang et al. (2018) HIV-1-Specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galactosylceramide Blocking and Phagocytosis. J Virol 92:
Paust, Silke; Blish, Catherine A; Reeves, R Keith (2017) Redefining Memory: Building the Case for Adaptive NK Cells. J Virol 91:
Shen, Xiaoying; Bogers, Willy M; Yates, Nicole L et al. (2017) Cross-Linking of a CD4-Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques. J Virol 91:

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