The overall goal of this PPG is to elucidate the molecular mechanisms of HCMV regulation of cellular signaling in the establishment and maintenance of viral latency and viral reactivation, as well as how viral dysregulation of HSC signaling may compromise hematopoiesis. To meet this goal we have assembled an extraordinary group of virologists who will collaborate in five highly interactive projects and two scientific cores. The Program Director (PD) and Principal Investigator of the Administrative Core is Jay Nelson, Ph.D., who is a senior molecular virologist with extensive experience studying the molecular interaction of cytomegaloviruses and their host environment. Dr. Nelson will be co-leading this program with Dr. Andrew Yurochko, who is an international expert in the study of Human Cytomegalovirus dissemination and pathogenesis. They will be assisted by an exceptional administrative team that has a proven track record in administering and managing large, complex grants and contracts such as the Pacific Northwest Regional Center of Excellence in Biodefense and Emerging Infectious Diseases (PNWRCE) and a NIAID Adjuvant Discovery Contract. The significant experience of this group with the organization, reporting and communications associated with the successful administration of multi-institutional research programs will be invaluable in ensuring a successful management of this PPG. The Administrative Core will serve as a hub for administration, communication and monitoring for the entire program. The core will serve all projects and all scientific cores, and it will interact with all institutions involved in this program. The Administrative Core will also serve as a central point of interaction with NIH Program. Finally, the administrative team will assist the program director in ensuring regular and timely communication among the members of this consortium as well as reporting to NIAID Program.
Large multi-institutional projects need to be coordinated by the lead institute. The Administrative Core will fulfill this role by providing administrative support to the Principal Investigators of this program, by arranging for regular meetings and other forms of exchange for ideas and data, by helping with and ensuring timely reporting, and by monitoring the progresses made by the program.
| Collins-McMillen, Donna; Chesnokova, Liudmila; Lee, Byeong-Jae et al. (2018) HCMV Infection and Apoptosis: How Do Monocytes Survive HCMV Infection? Viruses 10: |
| Crawford, Lindsey B; Kim, Jung Heon; Collins-McMillen, Donna et al. (2018) Human Cytomegalovirus Encodes a Novel FLT3 Receptor Ligand Necessary for Hematopoietic Cell Differentiation and Viral Reactivation. MBio 9: |
| Collins-McMillen, Donna; Stevenson, Emily V; Kim, Jung Heon et al. (2017) HCMV utilizes a non-traditional STAT1 activation cascade via signaling through EGFR and integrins to efficiently promote the motility, differentiation, and polarization of infected monocytes. J Virol : |
