This is a renewal grant application for an ongoing Program Project whose overall objectives have been the study of the chemistry, metabolism and molecular biology of connective tissues. The program is composed of 5 Subprojects and 2 Core Units. Project 1 will continue to investigate the mechanisms that regulate elastin gene expression and elastin fiber formation. Project 2 is a new Subproject; it will explore the mechanisms which regulate Type III collagen gene expression in cartilage. Project 3 will continue to investigate the nature and location of antigenic epitopes on Type IV collagen and examine structural and functional differences between laminins produced by normal and neoplastic cell lines. Project 4 will focus on studies which should explore the mechanisms of the nephritogenic immune response in interstitial nephritis. Project 5 will continue to utilize approaches that should help elucidate the molecular structure of genes which encode new collagen types. An Administrative Core Unit and a Core Laboratory Facility will supplement the research efforts.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Program Projects (P01)
Project #
5P01AR020553-19
Application #
2078446
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Project Start
1978-05-01
Project End
1997-04-30
Budget Start
1995-06-05
Budget End
1996-04-30
Support Year
19
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University City Science Center
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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