The broad, long-range objectives of this Program Project are to acquire and communicate new, fundamental knowledge on the chemistry, molecular structure, organization and physiological function of the cells and extracellular matrix of connective tissues, with particular reference to bone, cartilage, and enamel. Considerable effort will be directed to studies of tissue calcification and to the features which distinguish the skeletal and mineralized tissues from other connective tissues, since these specific characteristics are likely to play a critical role in defining their biological function. Our research projects cover all levels of anatomical hierarchy and molecular organization and the answers to important questions are being sought by integrating data from a wide diversity of scientific disciplines and techniques, including ultrastructural analysis, biochemistry, biophysics, and bioengineering. We feel that such a multifaceted but concentrated research effort on the basic biology and pathology of the skeletal system at the molecular, cellular, tissue, organ and whole organism levels will engender a more complete understanding of tissue calcification, calcified tissues and diarthrodial joints and provide a more rational basis for the diagnosis, treatment and prevention of the skeletal diseases that now disable a large part of the population.

Project Start
1983-01-01
Project End
1991-06-30
Budget Start
1989-07-01
Budget End
1990-06-30
Support Year
8
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
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Graham, L (1996) A comprehensive survey of the acid-stable fluorescent cross-links formed by ribose with basic amino acids, and partial characterization of a novel Maillard cross-link. Biochim Biophys Acta 1297:9-16
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