Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Program Projects (P01)
Project #
3P01AR043648-03S1
Application #
2794707
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Project Start
1995-08-10
Project End
2000-06-30
Budget Start
1998-01-01
Budget End
1998-06-30
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Physiology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Bridges, Charles R; Burkman, James M; Malekan, Ramin et al. (2002) Global cardiac-specific transgene expression using cardiopulmonary bypass with cardiac isolation. Ann Thorac Surg 73:1939-46
Croyle, M A; Chirmule, N; Zhang, Y et al. (2001) ""Stealth"" adenoviruses blunt cell-mediated and humoral immune responses against the virus and allow for significant gene expression upon readministration in the lung. J Virol 75:4792-801
Croyle, M A; Cheng, X; Sandhu, A et al. (2001) Development of novel formulations that enhance adenoviral-mediated gene expression in the lung in vitro and in vivo. Mol Ther 4:22-8
Zoltick, P W; Chirmule, N; Schnell, M A et al. (2001) Biology of E1-deleted adenovirus vectors in nonhuman primate muscle. J Virol 75:5222-9
Zhang, Y; Chirmule, N; Gao, G P et al. (2001) Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages. Mol Ther 3:697-707
Louboutin, J P; Rouger, K; Tinsley, J M et al. (2001) iNOS expression in dystrophinopathies can be reduced by somatic gene transfer of dystrophin or utrophin. Mol Med 7:355-64
Cordier, L; Gao, G P; Hack, A A et al. (2001) Muscle-specific promoters may be necessary for adeno-associated virus-mediated gene transfer in the treatment of muscular dystrophies. Hum Gene Ther 12:205-15
Gao, G; Qu, G; Burnham, M S et al. (2000) Purification of recombinant adeno-associated virus vectors by column chromatography and its performance in vivo. Hum Gene Ther 11:2079-91
Chirmule, N; Xiao, W; Truneh, A et al. (2000) Humoral immunity to adeno-associated virus type 2 vectors following administration to murine and nonhuman primate muscle. J Virol 74:2420-5
Cordier, L; Hack, A A; Scott, M O et al. (2000) Rescue of skeletal muscles of gamma-sarcoglycan-deficient mice with adeno-associated virus-mediated gene transfer. Mol Ther 1:119-29

Showing the most recent 10 out of 22 publications