The goal of this program of basic research is to understand how DNA tumor viruses transform normal cells into cancer cells. We are particularly interested in the mechanisms of gene regulation which are relevant to this process, namely the control of DNA replication, transcription, RNA processing and translation in mammalian cells; (ii) the structure and function of viral proteins which are involved in transformation; and (iii) the cellular responses to such proteins. These issues will be addressed through a coordinated, multidisciplinary program of research in the fields of genetics, molecular and cell biology, and biochemistry.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA013106-16
Application #
3092607
Study Section
Cancer Special Program Advisory Committee (CAK)
Project Start
1977-01-01
Project End
1991-12-31
Budget Start
1987-01-01
Budget End
1987-12-31
Support Year
16
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Cold Spring Harbor Laboratory
Department
Type
DUNS #
065968786
City
Cold Spring Harbor
State
NY
Country
United States
Zip Code
11724
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