Core F: Long-Term Follow-Up. This core supports Projects 1- 6 by collecting long-term follow-up data forpatients who have had hematopoietic cell transplantation at the Seattle Cancer Care Alliance, University ofWashington Medical Center or Children's Hospital and Regional Medical Center under protocols developedat the Fred Hutchinson Cancer Research Center as part of clinical research studies sponsored by thisprogram. The data provided through Core F are required for a variety of critically important purposes byprojects in this program: 1) capture of longer-term outcomes, including the occurrence of chronic GVHD,infections, recurrent or progressive malignancy, secondary malignancy and other anticipated latecomplications, as well as dates of last contact and death for patients enrolled in prospective research trials,2) capture of similar observational data for patients not enrolled in prospective studies, to be used forretrospective studies, 3) capture of observational data to be used for planning new clinical trials, and 4)capture of survivorship information to identify previously unrecognized late effects. A variety of mechanismswill be used to support these goals. a) We will continue to collect long-term data focused on survival, therapy-related complications, health and health-related quality of life relevant to the clinical research studies sponsored by this grant. These data concern the retrospective cohort of patients currently in follow-up from previous studies and the prospective cohort of patients to be enrolled .in studies described in Projects 1 - 6 of this grant application. For this purpose, a system has been established to track and maintain contact with patients and referring physicians so that data can be collected at specified time points after treatment. b)We will continue to assist investigators in obtaining long-term data specifically needed for individual research projects. c) We will continue to evaluate the methods employed in data collection and database management, identify barriers that interfere with long-term follow-up, and explore new technology to improve the efficiency and reliability of data collection and the validity and utility of the data.Relevance to Public Health: The data generated from this core unit will assist project leaders in theidentification of late complications In patients who have had blood or marrow cell transplantation fortreatment of leukemia, lymphoma, myeloma and other related disorders. The data will also provide the basisfor hypothesis-driven research concerning risk factors for late complications, the mechanisms leading to latecomplications, and the development of new approaches for preventing and managing late complicationsamong cancer survivors.
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