Abstract

Over the past 15 years the Division of Clinical Sciences of the Fred Hutchinson Cancer Research Center has been involved in a continuing program of marrow transplantation for the treatment of patients with otherwise fatal malignant and nonmalignant hematologic diseases. A number of patients have become long- term survivors with well functioning grafts and neither recurrence of their original disease nor occurrence of graft-versus-host disease. Many patients, however, have died because of graft failure, recurrent disease, or complications related to graft- versus-host disease. Further improvement of clinical marrow grafting results hinge upon this progress and better understanding in at least 5 major areas of study: 1) Methods of diagnosing, preventing and treating acute and chronic graft-versus-host disease, 2) reconstitution of immunological reactivity in marrow graft recipients, 3) lymphocyte marrow-cell interactions, 4) resistance to marrow grafts, and 5) immune mechanisms of graft- versus-host disease. It is the objective of this proposal to carry out immunological investigations in those 5 areas of study.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA018221-14
Application #
3092780
Study Section
Clinical Cancer Program Project Review Committee (CCP)
Project Start
1978-09-01
Project End
1991-11-30
Budget Start
1988-12-01
Budget End
1989-11-30
Support Year
14
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109

  Publications

Mielcarek, Marco; Storer, Barry E; Boeckh, Michael et al. (2009) Initial therapy of acute graft-versus-host disease with low-dose prednisone does not compromise patient outcomes. Blood 113:2888-94
Tseng, Li-Hui; Storer, Barry; Petersdorf, Effie et al. (2009) IL10 and IL10 receptor gene variation and outcomes after unrelated and related hematopoietic cell transplantation. Transplantation 87:704-10
Bensinger, W I (2009) Role of autologous and allogeneic stem cell transplantation in myeloma. Leukemia 23:442-8
Bensinger, William (2008) Stem-cell transplantation for multiple myeloma in the era of novel drugs. J Clin Oncol 26:480-92
Storek, Jan (2008) Immunological reconstitution after hematopoietic cell transplantation - its relation to the contents of the graft. Expert Opin Biol Ther 8:583-97
Bensinger, William I (2007) Is there still a role for allogeneic stem-cell transplantation in multiple myeloma? Best Pract Res Clin Haematol 20:783-95
Carpenter, Paul A; Hoffmeister, Paul; Chesnut 3rd, Charles H et al. (2007) Bisphosphonate therapy for reduced bone mineral density in children with chronic graft-versus-host disease. Biol Blood Marrow Transplant 13:683-90
Bensinger, William I (2007) Reduced intensity allogeneic stem cell transplantation in multiple myeloma. Front Biosci 12:4384-92
Zaucha, Renata E; Buckner, Dean C; Barnett, Todd et al. (2006) Modified total body irradiation as a planned second high-dose therapy with stem cell infusion for patients with bone-based malignancies. Int J Radiat Oncol Biol Phys 64:227-34
Alkindi, S; Deeg, J H; Flowers, M E D (2006) Recovery of normal autologous myelopoiesis after graft rejection following allogeneic bone marrow transplant for agnogenic myeloid metaplasia. Clin Lab Haematol 28:134-7

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