This program project will continue research in the use of heavy charged particles such as helium and neon ions for treatment of human cancers. The physical parameters of protons and helium ions permit precision charged particle radiation therapy to be delivered, resulting in highly significant clinical advances in the treatment of tumors lying close to critical normal structures in the eye, orbit, skull base, paranasal sinuses, juxtaspinal area, retroperitoneum or pelvis. Optimization of the use of these low-LET charged particles will continue, as LBL beam availability permits, through collaboration with other proton facilities in cooperative clinical trials. Neon ions, in addition to their dose-localizing properties, offer greater biological effectiveness because of their high-LET. Clinical promise has been seen in neon ion preliminary trials in bone and soft tissue sarcoma, prostate cancer, salivary gland tumors, skull base tumors such as nasopharynx and paranasal sinus cancers, juxtaspinal tumors and biliary tract tumors. Prospective trials are underway to determine whether dose- localization alone (Protons or Helium ions) is comparable to dose- localization + high-LET (Neon ions) therapy. Neon ions are also being compared to megavoltage low-LET therapy in treatment of prostate tumors and glioblastoma of the brain. It is expected that added clinical gains will be achieved through further research and development of improved treatment delivery techniques, specifically implementation of dynamic conformal heavy charged particle therapy. Potentially, highly significant improvement in high-LET charged particle therapy will be possible through much improved conformation f the high-LET dose zone to the tumor, with sparing of normal tissues both proximal and distal to the tumor. Improvements in treatment planning will be made to implement this highly promising form of charged particle therapy. The goals of the program are to optimize low-LET dose-localization therapy with protons and helium ions, and to study the application of high-LET beams such as neon ions in the treatment of human cancers.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA019138-20
Application #
2007216
Study Section
Special Emphasis Panel (SRC (A1))
Program Officer
Stone, Helen B
Project Start
1976-06-30
Project End
1999-11-30
Budget Start
1996-12-01
Budget End
1999-11-30
Support Year
20
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Lawrence Berkeley National Laboratory
Department
Radiation-Diagnostic/Oncology
Type
Organized Research Units
DUNS #
078576738
City
Berkeley
State
CA
Country
United States
Zip Code
94720
Mishra, Kavita K; Quivey, Jeanne M; Daftari, Inder K et al. (2015) Long-term Results of the UCSF-LBNL Randomized Trial: Charged Particle With Helium Ion Versus Iodine-125 Plaque Therapy for Choroidal and Ciliary Body Melanoma. Int J Radiat Oncol Biol Phys 92:376-83
Mori, Shinichiro; Dong, Lei; Starkschall, George et al. (2014) A serial 4DCT study to quantify range variations in charged particle radiotherapy of thoracic cancers. J Radiat Res 55:309-19
Mori, Shinichiro; Wolfgang, John; Lu, Hsiao-Ming et al. (2008) Quantitative assessment of range fluctuations in charged particle lung irradiation. Int J Radiat Oncol Biol Phys 70:253-61
Mori, Shinichiro; Chen, George T Y (2008) Quantification and visualization of charged particle range variations. Int J Radiat Oncol Biol Phys 72:268-77
Mori, Shinichiro; Chen, George T Y; Endo, Masahiro (2007) Effects of intrafractional motion on water equivalent pathlength in respiratory-gated heavy charged particle beam radiotherapy. Int J Radiat Oncol Biol Phys 69:308-17
Kaplan, I D; Castro, J R; Phillips, T L (1994) Helium charged particle radiotherapy for meningioma: experience at UCLBL. University of California Lawrence Berkeley Laboratory. Int J Radiat Oncol Biol Phys 28:257-61
Schoenthaler, R; Phillips, T L; Castro, J et al. (1994) Carcinoma of the extrahepatic bile ducts. The University of California at San Francisco experience. Ann Surg 219:267-74
Blakely, E A; Daftari, I K; Meecham, W J et al. (1994) Helium-ion-induced human cataractogenesis. Adv Space Res 14:501-5
Petti, P L; Kessler, M L; Fleming, T et al. (1994) An automated image-registration technique based on multiple structure matching. Med Phys 21:1419-26
Castro, J R; Linstadt, D E; Bahary, J P et al. (1994) Experience in charged particle irradiation of tumors of the skull base: 1977-1992. Int J Radiat Oncol Biol Phys 29:647-55

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