Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
3P01CA019589-08S4
Application #
3092844
Study Section
Clinical Cancer Program Project Review Committee (CCP)
Project Start
1976-06-30
Project End
1985-08-31
Budget Start
1983-07-01
Budget End
1985-08-31
Support Year
8
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
Rosowsky, A; Vaidya, C M; Bader, H et al. (1997) Analogues of N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523) modified in the side chain: synthesis and biological evaluation. J Med Chem 40:286-99
Teicher, B A; Holden, S A; Ara, G et al. (1996) Comparison of several antiangiogenic regimens alone and with cytotoxic therapies in the Lewis lung carcinoma. Cancer Chemother Pharmacol 38:169-77
Bharti, A K; Olson, M O; Kufe, D W et al. (1996) Identification of a nucleolin binding site in human topoisomerase I. J Biol Chem 271:1993-7
Dreyfuss, A I; Clark, J R; Norris, C M et al. (1996) Docetaxel: an active drug for squamous cell carcinoma of the head and neck. J Clin Oncol 14:1672-8
Robinson, M F; Dupuis, N P; Kusumoto, T et al. (1995) Increased tumor oxygenation and radiation sensitivity in two rat tumors by a hemoglobin-based, oxygen-carrying preparation. Artif Cells Blood Substit Immobil Biotechnol 23:431-8
Teicher, B A; Dupuis, N P; Emi, Y et al. (1995) Increased efficacy of chemo- and radio-therapy by a hemoglobin solution in the 9L gliosarcoma. In Vivo 9:11-8
Shapiro, C L; Dezube, B J; Tretyakov, O et al. (1995) Dose escalation of N,N',N""-triethylenethiophosphoramide combined with pentoxifylline for advanced breast cancer. Clin Cancer Res 1:791-6
Shapiro, G I; Edwards, C D; Kobzik, L et al. (1995) Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines. Cancer Res 55:505-9
Chen, G; Wright, J E; Rosowsky, A (1995) Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells. Mol Pharmacol 48:758-65
Teicher, B A; Holden, S A; Ara, G et al. (1995) Influence of an anti-angiogenic treatment on 9L gliosarcoma: oxygenation and response to cytotoxic therapy. Int J Cancer 61:732-7

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