Abstract

This multidisciplinary research program from the Department of Human Oncology and the Wisconsin Clinical Cancer Center utilizes both laboratory and clinical programs to achieve the goal of improving therapeutic effectiveness at all stages of the disease. Individual projects are directed at: 1) developing a breast cancer specific clonal assay and evaluating its predictive efficacy for breast cancer therapy; 2) improving the overall treatment of primary breast cancer; 3) understanding the basic biology of hormone dependency and determining the mechanism of action of estrogens and antiestrogens used in the treatment of breast cancer; 4) examining specific locus mutagenesis in human breast cells; 5) use of biostatistical support and computer-based data management to facilitate research; and 6) providing appropriate administrative support to enable the research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA020432-11
Application #
3092887
Study Section
Cancer Therapeutics Program Project Review Committee (CTR)
Project Start
1979-01-01
Project End
1989-05-31
Budget Start
1987-06-01
Budget End
1988-05-31
Support Year
11
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Type
Overall Medical
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Robins, H I; d'Oleire, F; Kutz, M et al. (1995) Cytotoxic interactions of tumor necrosis factor, melphalan and 41.8 degrees C hyperthermia. Cancer Lett 89:55-62
Helfand, S C; Soergel, S A; Modiano, J F et al. (1994) Induction of lymphokine-activated killer (LAK) activity in canine lymphocytes with low dose human recombinant interleukin-2 in vitro. Cancer Biother 9:237-44
Robins, H I; Cohen, J D; Schmitt, C L et al. (1993) Phase I clinical trial of carboplatin and 41.8 degrees C whole-body hyperthermia in cancer patients. J Clin Oncol 11:1787-94
Cohen, J D; Robins, H I; Katz, T B et al. (1993) Deoxyribonucleoside triphosphate pools and thymidine chemosensitization in human T-cell leukemia. Leuk Res 17:167-74
Storer, B E (1993) Small-sample confidence sets for the MTD in a phase I clinical trial. Biometrics 49:1117-25
Mahvi, D M; Carper, S W; Storm, F K et al. (1993) Overexpression of 27-kDa heat-shock protein in MCF-7 breast cancer cells: effects on lymphocyte-mediated killing by natural killer and gamma delta T cells. Cancer Immunol Immunother 37:181-6
Falkson, G; Tormey, D C; Carey, P et al. (1991) Long-term survival of patients treated with combination chemotherapy for metastatic breast cancer. Eur J Cancer 27:973-7
Jordan, V C (1991) Chemosuppression of breast cancer with long-term tamoxifen therapy. Prev Med 20:3-14
Jordan, V C; Fritz, N F; Langan-Fahey, S et al. (1991) Alteration of endocrine parameters in premenopausal women with breast cancer during long-term adjuvant therapy with tamoxifen as the single agent. J Natl Cancer Inst 83:1488-91
Goldstein, D; O'Leary, M; Mitchen, J et al. (1991) Effects of interferon beta ser and transforming growth factor beta on prostatic cell lines. J Urol 146:1173-7

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