This multidisciplinary research program from the Department of Human Oncology and the Wisconsin Clinical Cancer Center utilizes both laboratory and clinical programs to achieve the goal of improving therapeutic effectiveness at all stages of the disease. Individual projects are directed at: 1) developing a breast cancer specific clonal assay and evaluating its predictive efficacy for breast cancer therapy; 2) improving the overall treatment of primary breast cancer; 3) understanding the basic biology of hormone dependency and determining the mechanism of action of estrogens and antiestrogens used in the treatment of breast cancer; 4) examining specific locus mutagenesis in human breast cells; 5) use of biostatistical support and computer-based data management to facilitate research; and 6) providing appropriate administrative support to enable the research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
3P01CA020432-12S1
Application #
3092886
Study Section
Cancer Therapeutics Program Project Review Committee (CTR)
Project Start
1979-01-01
Project End
1990-06-30
Budget Start
1989-07-01
Budget End
1990-06-30
Support Year
12
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
Overall Medical
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
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Goldstein, D; O'Leary, M; Mitchen, J et al. (1991) Effects of interferon beta ser and transforming growth factor beta on prostatic cell lines. J Urol 146:1173-7

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