Abstract

The Pediatric Oncology Program Project is an integrated grant covering clinical and preclinical studies in oncology and bone marrow transplantation. A major emphasis of this grant is related to therapeutic investigations with emphasis on marrow transplantation for the treatment of acute leukemia, non-Hodgkin's lymphoma, neuroblastoma, aplastic anemia, and for patients at high risk for kidney graft rejection. Children and adults will be treated in these studies. Emphasis is on total lymphoid irradiation and T-cell depletion of donor bone marrow to reduce the risk of development of graft versus host disease. Preclinical investigations form a major portion of this grant, complementing and interdigitating with the therapeutic studies. Included are investigations into the nature and function of committed hematopoietic marrow cells, platelet pathophysiology, cyclophosphamide metabolism, and adrenergic mechanisms in neuroblastoma. Studies of the etiology of childhood cancers will include evaluation of the role of DNA repair mechanisms and tumor viruses.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA021737-10
Application #
3092959
Study Section
Clinical Cancer Program Project Review Committee (CCP)
Project Start
1984-03-01
Project End
1988-02-29
Budget Start
1987-03-01
Budget End
1988-02-29
Support Year
10
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Flynn, Catherine M; Hirsch, Betsy; Defor, Todd et al. (2007) Reduced intensity compared with high dose conditioning for allotransplantation in acute myeloid leukemia and myelodysplastic syndrome: a comparative clinical analysis. Am J Hematol 82:867-72
Orchard, Paul J; Blazar, Bruce R; Wagner, John et al. (2007) Hematopoietic cell therapy for metabolic disease. J Pediatr 151:340-6
Grewal, Satkiran S; Barker, Juliet N; Davies, Stella M et al. (2003) Unrelated donor hematopoietic cell transplantation: marrow or umbilical cord blood? Blood 101:4233-44
Wagner, John E; Barker, Juliet N; DeFor, Todd E et al. (2002) Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood 100:1611-8
Sladek, Norman E (2002) Leukemic cell insensitivity to cyclophosphamide and other oxazaphosphorines mediated by aldehyde dehydrogenase(s). Cancer Treat Res 112:161-75
Browne, P V; Weisdorf, D J; DeFor, T et al. (2000) Response to thalidomide therapy in refractory chronic graft-versus-host disease. Bone Marrow Transplant 26:865-9
Delforge, M; Boogaerts, M A; McGlave, P B et al. (1999) BCR/ABL- CD34(+)HLA-DR- progenitor cells in early chronic phase, but not in more advanced phases, of chronic myelogenous leukemia are polyclonal. Blood 93:284-92
Warwick, A B; Mertens, A C; Shu, X O et al. (1998) Outcomes following mechanical ventilation in children undergoing bone marrow transplantation. Bone Marrow Transplant 22:787-94
Katsanis, E; Weisdorf, D J; Miller, J S (1998) Activated peripheral blood mononuclear cells from patients receiving subcutaneous interleukin-2 following autologous stem cell transplantation prolong survival of SCID mice bearing human lymphoma. Bone Marrow Transplant 22:185-91
Arns da Cunha, C; Weisdorf, D; Shu, X O et al. (1998) Early gram-positive bacteremia in BMT recipients: impact of three different approaches to antimicrobial prophylaxis. Bone Marrow Transplant 21:173-80

Showing the most recent 10 out of 416 publications