For the past nine years, the Transplantation Biology Unit at UCLA has been involved in a continuing program of bone marrow transplantation in the treatment of patients with aplastic anemia, leukemia, cancer, and immunodeficiency diseases. Many of these patients have become long-term survivors but considerable problems remain to be addressed including prevention of graft rejection, graft-vs-host disease (GVHD), delay of immune reconstitution and interstitial pneumonia. This proposal outlines our ongoing studies in three major program areas: (1) the immunobiology of marrow transplantation, and (3) interstitial pneumoia in transplant recipients. These studies include preclinical studies in dogs, and controlled clinical trials. The objective of the proposed project is to continue progress in the application of bone marrow transplantation to human disease by an in-depth analysis of basic problems of transplantation biology in animals and by appropriate clinical trials.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA023175-07
Application #
3093047
Study Section
Clinical Cancer Program Project Review Committee (CCP)
Project Start
1983-07-15
Project End
1987-06-30
Budget Start
1986-06-01
Budget End
1987-06-30
Support Year
7
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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Marin, T; Butturini, A; Kantarjian, H et al. (1992) Survival of children with chronic myeloid leukemia. Am J Pediatr Hematol Oncol 14:229-32

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