Abstract

The research program described here is designed to study the immunopathological and oncological consequences of endogenous retroviral gene expression. Basically, these studies represent a continuation of the efforts of a research team which has been functioning together on this project for eight years. The basic concept which draws the research efforts together is the realization that many host factors determine the outcome of endogenous retroviral gene expression and to approach a final understanding of how these viruses cause disease requires cooperation between investigators studying the molecular nature of the genes per se as well as those who understand how host defense systems impinge upon viral replication and viral gene expression in the absence of viral replication. Thus, within the confines of this program project we will study: a) the nature of the genes and gene products which give rise to leukemogenic transformation, b) the mechanism by which the complement cascade recognizes and lyses retroviruses, c) the immunopathological consequences of endogenous retroviral gene expression with particular emphasis on immune complex disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA027489-06
Application #
3093169
Study Section
Cancer Special Program Advisory Committee (CAK)
Project Start
1980-05-01
Project End
1990-04-30
Budget Start
1985-05-01
Budget End
1986-04-30
Support Year
6
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Scripps Research Institute
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92037

  Publications

Zhu, Xueyong; Tanaka, Fujie; Lerner, Richard A et al. (2009) Direct observation of an enamine intermediate in amine catalysis. J Am Chem Soc 131:18206-7
Kamikubo, Yuichi; Kroon, Gerard; Curriden, Scott A et al. (2006) The reduced, denatured somatomedin B domain of vitronectin refolds into a stable, biologically active molecule. Biochemistry 45:3297-306
Zhu, Xueyong; Wentworth Jr, Paul; Kyle, Robert A et al. (2006) Cofactor-containing antibodies: crystal structure of the original yellow antibody. Proc Natl Acad Sci U S A 103:3581-5
Steiner, Derek D; Mase, Nobuyuki; Barbas 3rd, Carlos F (2005) Direct asymmetric alpha-fluorination of aldehydes. Angew Chem Int Ed Engl 44:3706-10
Suri, Jeff T; Ramachary, Dhevalapally B; Barbas 3rd, Carlos F (2005) Mimicking dihydroxy acetone phosphate-utilizing aldolases through organocatalysis: a facile route to carbohydrates and aminosugars. Org Lett 7:1383-5
Chowdari, Naidu S; Barbas 3rd, Carlos F (2005) Total synthesis of LFA-1 antagonist BIRT-377 via organocatalytic asymmetric construction of a quaternary stereocenter. Org Lett 7:867-70
Ramachary, Dhevalapally B; Barbas 3rd, Carlos F (2005) Direct amino acid-catalyzed asymmetric desymmetrization of meso-compounds: tandem aminoxylation/O-N bond heterolysis reactions. Org Lett 7:1577-80
Suri, Jeff T; Steiner, Derek D; Barbas 3rd, Carlos F (2005) Organocatalytic enantioselective synthesis of metabotropic glutamate receptor ligands. Org Lett 7:3885-8
Tanaka, Fujie; Fuller, Roberta; Barbas 3rd, Carlos F (2005) Development of small designer aldolase enzymes: catalytic activity, folding, and substrate specificity. Biochemistry 44:7583-92
Heine, Andreas; Luz, John G; Wong, Chi-Huey et al. (2004) Analysis of the class I aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99A resolution. J Mol Biol 343:1019-34

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