Abstract

The Core is intended to provide necessary support for the research work in this program in two areas, firstly in providing biochemical and molecular biological infrastructure for all four projects and secondly in supporting the infrastructure of the NMR and X-ray efforts, in proportion to the usage that this program is anticipated to make of these facilities. Many of the hybridomas and immunoglobulins necessary for the two structural projects will be provided by the core, and it is anticipated that all four projects will rely heavily on the expertise of core personnel.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA027489-19
Application #
6269102
Study Section
Project Start
1998-03-01
Project End
1999-02-28
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
19
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Zhu, Xueyong; Tanaka, Fujie; Lerner, Richard A et al. (2009) Direct observation of an enamine intermediate in amine catalysis. J Am Chem Soc 131:18206-7
Kamikubo, Yuichi; Kroon, Gerard; Curriden, Scott A et al. (2006) The reduced, denatured somatomedin B domain of vitronectin refolds into a stable, biologically active molecule. Biochemistry 45:3297-306
Zhu, Xueyong; Wentworth Jr, Paul; Kyle, Robert A et al. (2006) Cofactor-containing antibodies: crystal structure of the original yellow antibody. Proc Natl Acad Sci U S A 103:3581-5
Steiner, Derek D; Mase, Nobuyuki; Barbas 3rd, Carlos F (2005) Direct asymmetric alpha-fluorination of aldehydes. Angew Chem Int Ed Engl 44:3706-10
Suri, Jeff T; Ramachary, Dhevalapally B; Barbas 3rd, Carlos F (2005) Mimicking dihydroxy acetone phosphate-utilizing aldolases through organocatalysis: a facile route to carbohydrates and aminosugars. Org Lett 7:1383-5
Chowdari, Naidu S; Barbas 3rd, Carlos F (2005) Total synthesis of LFA-1 antagonist BIRT-377 via organocatalytic asymmetric construction of a quaternary stereocenter. Org Lett 7:867-70
Ramachary, Dhevalapally B; Barbas 3rd, Carlos F (2005) Direct amino acid-catalyzed asymmetric desymmetrization of meso-compounds: tandem aminoxylation/O-N bond heterolysis reactions. Org Lett 7:1577-80
Suri, Jeff T; Steiner, Derek D; Barbas 3rd, Carlos F (2005) Organocatalytic enantioselective synthesis of metabotropic glutamate receptor ligands. Org Lett 7:3885-8
Tanaka, Fujie; Fuller, Roberta; Barbas 3rd, Carlos F (2005) Development of small designer aldolase enzymes: catalytic activity, folding, and substrate specificity. Biochemistry 44:7583-92
Heine, Andreas; Luz, John G; Wong, Chi-Huey et al. (2004) Analysis of the class I aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99A resolution. J Mol Biol 343:1019-34

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