Our previous investigations have centered on a population-based study in Colombia to determine whether nitrate, N-nitrosoproline (NPro) and/or 3- methyladenine were related to the histopathological status of the gastric mucosa. We have discovered that only individuals diagnosed as having intestinal metaplasia or dysplasia (IM) of the stomach show a high degree of correlation between urinary nitrate and urinary N-nitrosoproline. Individuals with normal or chronic gastritis mucosa showed no correlation. A possible explanation for this observation is the loss of reduced ascorbic acid from gastric juice of IM individuals. We will further test the hypothesis that IM leads to increased synthesis of N-nitroso compounds and that increased dietary ascorbic acid inhibits nitrosation. In addition to direct measures of N-nitroso compounds, 15NO3 will be used to establish gastric losses and incorporation of 15N into NPro in individuals with IM compared to normal gastric mucosa. This proposal is a further test of the hypothesis that endogenously formed N-nitroso compounds are risk factors for gastric cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA028842-12
Application #
3749785
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Louisiana State University Hsc New Orleans
Department
Type
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112
Singh, Kshipra; Coburn, Lori A; Asim, Mohammad et al. (2018) Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses. Cancer Res 78:4303-4315
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