Abstract

Our previous investigations have centered on a population-based study in Colombia to determine whether nitrate, N-nitrosoproline (NPro) and/or 3- methyladenine were related to the histopathological status of the gastric mucosa. We have discovered that only individuals diagnosed as having intestinal metaplasia or dysplasia (IM) of the stomach show a high degree of correlation between urinary nitrate and urinary N-nitrosoproline. Individuals with normal or chronic gastritis mucosa showed no correlation. A possible explanation for this observation is the loss of reduced ascorbic acid from gastric juice of IM individuals. We will further test the hypothesis that IM leads to increased synthesis of N-nitroso compounds and that increased dietary ascorbic acid inhibits nitrosation. In addition to direct measures of N-nitroso compounds, 15NO3 will be used to establish gastric losses and incorporation of 15N into NPro in individuals with IM compared to normal gastric mucosa. This proposal is a further test of the hypothesis that endogenously formed N-nitroso compounds are risk factors for gastric cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
3P01CA028842-12S1
Application #
3729696
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Louisiana State University Hsc New Orleans
Department
Type
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112

  Publications

Bravo, Luis Eduardo; García, Luz Stella; Collazos, Paola et al. (2018) Reliable information for cancer control in Cali, Colombia. Colomb Med (Cali) 49:23-34
Mera, Robertino M; Bravo, Luis E; Camargo, M Constanza et al. (2018) Dynamics of Helicobacter pylori infection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trial. Gut 67:1239-1246
García, Luz Stella; Bravo, Luis Eduardo; Collazos, Paola et al. (2018) Cali cancer registry methods. Colomb Med (Cali) 49:109-120
Singh, Kshipra; Coburn, Lori A; Asim, Mohammad et al. (2018) Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses. Cancer Res 78:4303-4315
Ge, Zhongming; Sheh, Alexander; Feng, Yan et al. (2018) Helicobacter pylori-infected C57BL/6 mice with different gastrointestinal microbiota have contrasting gastric pathology, microbial and host immune responses. Sci Rep 8:8014
Gobert, Alain P; Al-Greene, Nicole T; Singh, Kshipra et al. (2018) Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection. Front Immunol 9:1242
Estevez-Ordonez, Dagoberto; Montalvan-Sanchez, Eleazar E; Wong, Rochelle E et al. (2018) Health Barriers and Patterns of Gastric Cancer Care in Rural Central American Resource-Limited Settings. JAMA Oncol 4:1131-1133
Scoville, Elizabeth A; Allaman, Margaret M; Brown, Caroline T et al. (2018) Alterations in Lipid, Amino Acid, and Energy Metabolism Distinguish Crohn's Disease from Ulcerative Colitis and Control Subjects by Serum Metabolomic Profiling. Metabolomics 14:
Sierra, Johanna C; Asim, Mohammad; Verriere, Thomas G et al. (2018) Epidermal growth factor receptor inhibition downregulates Helicobacter pylori-induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis. Gut 67:1247-1260
Blosse, Alice; Lehours, Philippe; Wilson, Keith T et al. (2018) Helicobacter: Inflammation, immunology, and vaccines. Helicobacter 23 Suppl 1:e12517

Showing the most recent 10 out of 278 publications