Abstract

The objective of this Program Project is the multidisciplinary study of the etiology of gastric cancer, focused on premalignant lesions. The current cycle is based on findings of the previous funding cycles which have led to the postulation and refinement of an etiologic model. The first project is the continuation of a chemoprevention trial designed to determine the efficacy of antioxidant supplementation (ascorbic acid and/or beta carotene) and/or anti-Helicobacter pylori treatment in retarding the progression of the premalignant process. The second project provides an evaluation of the histological and molecular endpoints used in all the other components of the program. All of the proposed studies are closely interrelated and complementary. They explore the mechanisms of action of the factors involved in the gastric precancerous process and its possible inhibition. These studies have the potential to provide important new knowledge about gastric carcinogenesis and to contribute to the goal of primary prevention of this common cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA028842-16
Application #
2882300
Study Section
Cancer Centers and Research Programs Review Committee (CCRP)
Program Officer
Patel, Appasaheb1 R
Project Start
1981-06-01
Project End
2001-02-28
Budget Start
1999-03-04
Budget End
2000-02-29
Support Year
16
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Louisiana State University Hsc New Orleans
Department
Pathology
Type
Schools of Dentistry
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112

  Publications

Singh, Kshipra; Coburn, Lori A; Asim, Mohammad et al. (2018) Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses. Cancer Res 78:4303-4315
Ge, Zhongming; Sheh, Alexander; Feng, Yan et al. (2018) Helicobacter pylori-infected C57BL/6 mice with different gastrointestinal microbiota have contrasting gastric pathology, microbial and host immune responses. Sci Rep 8:8014
Gobert, Alain P; Al-Greene, Nicole T; Singh, Kshipra et al. (2018) Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection. Front Immunol 9:1242
Estevez-Ordonez, Dagoberto; Montalvan-Sanchez, Eleazar E; Wong, Rochelle E et al. (2018) Health Barriers and Patterns of Gastric Cancer Care in Rural Central American Resource-Limited Settings. JAMA Oncol 4:1131-1133
Scoville, Elizabeth A; Allaman, Margaret M; Brown, Caroline T et al. (2018) Alterations in Lipid, Amino Acid, and Energy Metabolism Distinguish Crohn's Disease from Ulcerative Colitis and Control Subjects by Serum Metabolomic Profiling. Metabolomics 14:
Sierra, Johanna C; Asim, Mohammad; Verriere, Thomas G et al. (2018) Epidermal growth factor receptor inhibition downregulates Helicobacter pylori-induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis. Gut 67:1247-1260
Blosse, Alice; Lehours, Philippe; Wilson, Keith T et al. (2018) Helicobacter: Inflammation, immunology, and vaccines. Helicobacter 23 Suppl 1:e12517
Piñeros, Marion; Frech, Silvina; Frazier, Lindsay et al. (2018) Advancing Reliable Data for Cancer Control in the Central America Four Region. J Glob Oncol :1-11
González-Pons, María; Soto-Salgado, Marievelisse; Sevilla, Javier et al. (2018) Seroprevalence of Helicobacter pylori in Hispanics living in Puerto Rico: A population-based study. Helicobacter 23:
Coburn, Lori A; Singh, Kshipra; Asim, Mohammad et al. (2018) Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis. Oncogene :

Showing the most recent 10 out of 278 publications