Abstract

The goal of this project is to simplify and refine the Scanned, Intensity-Modulated Focused Ultrasound (SIMFU) system to enhance its versatility to heat larger and deeper tumors with safety and to make it suitable for routine clinical use in a Hospital setting. The present SIMFU will be upgraded by replacement of some of its substandard and obsolete components. A dual-portal insonation system which will permit easier, faster and more effective coupling to different regions of the body will be developed. Pre-Treatment Predictive Therapy Planning, Automatic Monitoring and Control during Therapy and Post- Treatment Reconstruction of Tissue Temperature Fields will be implemented. To ensure safety, thresholds of cavitation damage to solid tissues will be studied and the safety and efficacy of """"""""Rapid Hyperthermia"""""""" will be studied in experimental animals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA031303-05
Application #
3816522
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Hurwitz, Mark D; Hansen, Jorgen L; Prokopios-Davos, Savina et al. (2011) Hyperthermia combined with radiation for the treatment of locally advanced prostate cancer: long-term results from Dana-Farber Cancer Institute study 94-153. Cancer 117:510-6
Wang, XiaoZhe; Khaleque, Md Abdul; Zhao, Mei Juan et al. (2006) Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding. J Biol Chem 281:782-91
Calderwood, S K (2005) Evolving connections between molecular chaperones and neuronal function. Int J Hyperthermia 21:375-8
Tang, Dan; Khaleque, Md Abdul; Jones, Ellen L et al. (2005) Expression of heat shock proteins and heat shock protein messenger ribonucleic acid in human prostate carcinoma in vitro and in tumors in vivo. Cell Stress Chaperones 10:46-58
Calderwood, Stuart K; Theriault, Jimmy R; Gong, Jianlin (2005) Message in a bottle: role of the 70-kDa heat shock protein family in anti-tumor immunity. Eur J Immunol 35:2518-27
Ciocca, Daniel R; Calderwood, Stuart K (2005) Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones 10:86-103
Tonkiss, J; Calderwood, S K (2005) Regulation of heat shock gene transcription in neuronal cells. Int J Hyperthermia 21:433-44
Khaleque, Md Abdul; Bharti, Ajit; Sawyer, Douglas et al. (2005) Induction of heat shock proteins by heregulin beta1 leads to protection from apoptosis and anchorage-independent growth. Oncogene 24:6564-73
Hurwitz, Mark D; Kaplan, Irving D; Hansen, Jorgen L et al. (2005) Hyperthermia combined with radiation in treatment of locally advanced prostate cancer is associated with a favourable toxicity profile. Int J Hyperthermia 21:649-56
Calderwood, Stuart K (2005) Regulatory interfaces between the stress protein response and other gene expression programs in the cell. Methods 35:139-48

Showing the most recent 10 out of 52 publications