Abstract

The technical and clinical Core A will provide major clinical and technical support to Project I (Clinical) and Project 3 (Technical). Minor thermometry and quality assurance support will be given to Project 2 (Biology). The specific areas of support will be; . Support of treatment devices. . Treatment planning and clinical support. . Development of tools for the clinic. . Phantom testing, and QA of equipment, software and thermometry. . Coordinate validation of models and thermometry using pigs. Core A has two subcontracts; one with Massachusetts Institute of Technology (MIT) and one with Brigham and Women's Hospital (BWH). The MIT subcontract (Dr. Bowman) supports the modification of the 14-sensor temperature profilometer to a multi-sensor temperature and perfusion measurement probe. The MIT component also support the clinical use (Project 1) of these probes and the animal validation studies necessary for Project 3. The BWH subcontract (Dr. Hynynen) is responsible for the maintenance and quality control of the transrectal multi-transducer applicator, which will be used for prostate treatments. This core component also provides clinical oversight and clinical participation of the prostate treatment procedure.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA031303-11
Application #
6236641
Study Section
Project Start
1997-06-01
Project End
1998-05-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
11
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Hurwitz, Mark D; Hansen, Jorgen L; Prokopios-Davos, Savina et al. (2011) Hyperthermia combined with radiation for the treatment of locally advanced prostate cancer: long-term results from Dana-Farber Cancer Institute study 94-153. Cancer 117:510-6
Wang, XiaoZhe; Khaleque, Md Abdul; Zhao, Mei Juan et al. (2006) Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding. J Biol Chem 281:782-91
Hurwitz, Mark D; Kaplan, Irving D; Hansen, Jorgen L et al. (2005) Hyperthermia combined with radiation in treatment of locally advanced prostate cancer is associated with a favourable toxicity profile. Int J Hyperthermia 21:649-56
Calderwood, Stuart K (2005) Regulatory interfaces between the stress protein response and other gene expression programs in the cell. Methods 35:139-48
Calderwood, Stuart K; Theriault, Jimmy R; Gong, Jianlin (2005) How is the immune response affected by hyperthermia and heat shock proteins? Int J Hyperthermia 21:713-6
Calderwood, S K (2005) Evolving connections between molecular chaperones and neuronal function. Int J Hyperthermia 21:375-8
Tang, Dan; Khaleque, Md Abdul; Jones, Ellen L et al. (2005) Expression of heat shock proteins and heat shock protein messenger ribonucleic acid in human prostate carcinoma in vitro and in tumors in vivo. Cell Stress Chaperones 10:46-58
Calderwood, Stuart K; Theriault, Jimmy R; Gong, Jianlin (2005) Message in a bottle: role of the 70-kDa heat shock protein family in anti-tumor immunity. Eur J Immunol 35:2518-27
Ciocca, Daniel R; Calderwood, Stuart K (2005) Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones 10:86-103
Tonkiss, J; Calderwood, S K (2005) Regulation of heat shock gene transcription in neuronal cells. Int J Hyperthermia 21:433-44

Showing the most recent 10 out of 52 publications