Abstract

This is an integrated research program in medical oncology focused on oncogenes, viral oncogenesis, growth factors, and their role in human neoplasia. The investigations are of a basic nature, emphasizing human tissues, viruses, and proteins, and the methodologies employed rely heavily on molecular and cell biology and protein analysis and purification. The specific projects are: 1. Comparative Biology of HTLV-I and HTLV-II. 2. Introduction of Macromolecules into Mammalian Cells. 3. Mechanism of Adenovirus Transformation. 4. Viral Trans-acting Transcriptional Regulation. 5. Regulation of Expression of Human Erythroid-potentiating Activity and GM-colony-stimulating Factor. 6. Role of the abl Oncogene in Human Chronic Myelogenous Leukemia. 7. Studies on the Putative Transforming Proteins of the Human T-cell Leukemia Viruses, HTLV-I and HTLV-II. 8. p53: Role in Normal and Malignant Growth and Differentiation. 9. Regulators of Human Macrophage Proliferation and Function: Molecular and Biologic Studies. Each project in this program contributes toward the aim of understanding the biologic basis of neoplasia for the purpose of furthering the general goal of improved prevention and treatment of human cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA032737-07
Application #
3093468
Study Section
Cancer Special Program Advisory Committee (CAK)
Project Start
1982-04-01
Project End
1991-03-31
Budget Start
1988-04-19
Budget End
1989-03-31
Support Year
7
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

O'Brien, Neil A; McDonald, Karen; Tong, Luo et al. (2014) Targeting PI3K/mTOR overcomes resistance to HER2-targeted therapy independent of feedback activation of AKT. Clin Cancer Res 20:3507-20
Short, John D; Dere, Ruhee; Houston, Kevin D et al. (2010) AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. Mol Carcinog 49:429-39
Lu, Jie; Chan, Lai; Fiji, Hannah D G et al. (2009) In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I. Mol Cancer Ther 8:1218-26
Klichko, Yaroslav; Liong, Monty; Choi, Eunshil et al. (2009) Mesostructured Silica for Optical Functionality, Nanomachines, and Drug Delivery. J Am Ceram Soc 92:s2-s10
Short, John D; Houston, Kevin D; Dere, Ruhee et al. (2008) AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27. Cancer Res 68:6496-506
Lu, Jie; Choi, Eunshil; Tamanoi, Fuyuhiko et al. (2008) Light-activated nanoimpeller-controlled drug release in cancer cells. Small 4:421-6
Liong, Monty; Lu, Jie; Kovochich, Michael et al. (2008) Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery. ACS Nano 2:889-96
Watanabe, Masaru; Fiji, Hannah D G; Guo, Lea et al. (2008) Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds. J Biol Chem 283:9571-9
Lu, Jie; Liong, Monty; Sherman, Sean et al. (2007) Mesoporous Silica Nanoparticles for Cancer Therapy: Energy-Dependent Cellular Uptake and Delivery of Paclitaxel to Cancer Cells. Nanobiotechnology 3:89-95
Lu, Jie; Liong, Monty; Zink, Jeffrey I et al. (2007) Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs. Small 3:1341-6

Showing the most recent 10 out of 213 publications