Abstract

Core C provides the instruments, techniques, personnel and expertise necessary for in vivo quantification of the distribution of radioactivity in large animals and human beings. This Core has three main types of activities: supervision of the performance of scans, development and implementation of new acquisition and image processing techniques, and collaboration with each Project in the optimization of acquisition and processing protocols. This Core contains the instrumentation, image processing workstations, techniques for data acquisition and processing, and the personnel responsible for the Core's operation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA032845-34
Application #
5207161
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
34
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Madar, Igal; Bencherif, Badredin; Lever, John et al. (2007) Imaging delta- and mu-opioid receptors by PET in lung carcinoma patients. J Nucl Med 48:207-13
Lin, Kuo-Shyan; Luu, Andrew; Baidoo, Kwamena E et al. (2005) A new high affinity technetium-99m-bombesin analogue with low abdominal accumulation. Bioconjug Chem 16:43-50
Hardwick, Matthew J; Chen, Ming-Kai; Baidoo, Kwamena et al. (2005) In vivo imaging of peripheral benzodiazepine receptors in mouse lungs: a biomarker of inflammation. Mol Imaging 4:432-8
Chen, Ming-Kai; Baidoo, Kwamena; Verina, Tatyana et al. (2004) Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization. Brain 127:1379-92
Lin, Kuo-Shyan; Luu, Andrew; Baidoo, Kwamena E et al. (2004) A new high affinity technetium analogue of bombesin containing DTPA as a pharmacokinetic modifier. Bioconjug Chem 15:1416-23
Lever, J R; Ilgin, N; Musachio, J L et al. (1998) Autoradiographic and SPECT imaging of cerebral opioid receptors with an iodine-123 labeled analogue of diprenorphine. Synapse 29:172-82
Sanchez-Roa, P M; Wagner Jr, H N; Villemagne, V L et al. (1998) Effects of extracellular acetylcholine on muscarinic receptor binding assessed by [125I]dexetimide and a simple probe. Eur J Pharmacol 358:207-11
Baidoo, K E; Lin, K S; Zhan, Y et al. (1998) Design, synthesis, and initial evaluation of high-affinity technetium bombesin analogues. Bioconjug Chem 9:218-25
Baidoo, K E; Scheffel, U; Stathis, M et al. (1998) High-affinity no-carrier-added 99mTc-labeled chemotactic peptides for studies of inflammation in vivo. Bioconjug Chem 9:208-17
Kao, C H; Baidoo, K E; Lever, S Z (1997) Validation and application of a solid phase chemistry method for preparation of high effective specific activity technetium-99m radiopharmaceuticals. Nucl Med Biol 24:499-505

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