This program is concerned with the effects of biological response modifiers on cancer and on the immune and hematopoietic system. We will pursue two principal approaches - the study of agents whose primary action does not involve a specific immune response to cancer antigens, and the investigation of modalities that utilize current knowledge of cancer-specific antigens and of immune reactions directed against them. Agents to be investigated in the first category include interferons, thymic fractions, bacterial lipopolysaccharide and other bacterial products. In the second category, we will investigate the serological response to vaccines containing serologically defined cancer cell surface antigens, the possibility of augmenting the response by manipulations aimed at reducing suppressor cell activity, and the use of monoclonal antibodies against cancer cell surface antigens in diagnosis and therapy. The clinical program depends on, and is backed up by, extensive laboratory investigation.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA033049-06
Application #
3093496
Study Section
Clinical Cancer Program Project Review Committee (CCP)
Project Start
1982-07-01
Project End
1989-02-28
Budget Start
1987-08-01
Budget End
1989-02-28
Support Year
6
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Memorial Hospital for Cancer & Allied Di
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10021
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