This chemoprevention trial tests the efficacy of retinol and beta- carotene in preventing lung cancer in two related high-risk populations: (a) heavy smokers recruited from insurance-based sources, and (b) current and former workers with heavy occupational asbestos exposure recruited from workers' compensation and employment-based sources. The double-blind, two-arm, randomized trial compares placebos with a daily combination of 30 mg beta- carotene plus 25,000 IU retinol. Successful recruitment, excellent compliance, and minimal side effects have been shown thus far in over 1700 subjects enrolled in our two current chemoprevention projects using these agents. We propose to integrate the two high- risk populations in a cost-effective, multi-clinic strategy for this efficacy trial, with Seattle coordinating center for project management and data analysis. During the first three years of the new grant period (1988-91) we will evaluate accrual, coordination, and costs in five geographically-dispersed clinic sites to generate best estimates of the remaining needs for the full-scale enrollment and follow-up. Current assumptions and projections indicate that the full-scale study will be capable of detecting significant reductions in lung cancer incidence in the high-risk groups combined, and in either subgroup alone, with 13,000 smokers and 4000 asbestos-exposed subjects.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA034847-08
Application #
3812482
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109
Satia, Jessie A; Kristal, Alan R; Patterson, Ruth E et al. (2002) Psychosocial factors and dietary habits associated with vegetable consumption. Nutrition 18:247-54
Levy, L; Patterson, R E; Kristal, A R et al. (2000) How well do consumers understand percentage daily value on food labels? Am J Health Promot 14:157-60, ii
Peterson Jr, A V; Kealey, K A; Mann, S L et al. (2000) Hutchinson Smoking Prevention Project: long-term randomized trial in school-based tobacco use prevention--results on smoking. J Natl Cancer Inst 92:1979-91
Satia, J A; Patterson, R E; Taylor, V M et al. (2000) Use of qualitative methods to study diet, acculturation, and health in Chinese-American women. J Am Diet Assoc 100:934-40
Neuhouser, M L; Kristal, A R; Patterson, R E (1999) Use of food nutrition labels is associated with lower fat intake. J Am Diet Assoc 99:45-53
Patterson, R E; Levy, L; Tinker, L F et al. (1999) Evaluation of a simplified vitamin supplement inventory developed for the Women's Health Initiative. Public Health Nutr 2:273-6
Kristal, A R; Glanz, K; Curry, S J et al. (1999) How can stages of change be best used in dietary interventions? J Am Diet Assoc 99:679-84
Neuhouser, M L; Patterson, R E; Levy, L (1999) Motivations for using vitamin and mineral supplements. J Am Diet Assoc 99:851-4
Patterson, R E; Kristal, A R; Levy, L et al. (1998) Validity of methods used to assess vitamin and mineral supplement use. Am J Epidemiol 148:643-9
Patterson, R E; Kristal, A R; Shannon, J et al. (1997) Using a brief household food inventory as an environmental indicator of individual dietary practices. Am J Public Health 87:272-5

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